亚甲蓝染色法检测甲状腺乳头状癌前哨淋巴结的临床研究

目的探讨甲状腺乳头状癌前哨淋巴结（SN）的检测方法及其对颈淋巴结转移的预测价值。方法术中使用亚甲蓝对24例甲状腺乳头状癌患者进行SN示踪，观察冷冻快速切片检查SN转移与常规病理淋巴结转移的符合率，及SN对颈淋巴结转移的预测价值。结果24例中成功检出21例SN，成功率为87．5％，SN平均每例3枚；1例假阴性，假阴性率为4．8％（1／21）；无假阳性。SN对颈淋巴结转移阳性预测值为83．3％。结论亚甲蓝染色法检测SN可较准确地预测甲状腺乳头状癌的颈淋巴结转移状况。

Clinical study of methylene blue staining to indentify sentinel lymph nodes in thyroid papillary carcinoma

Objective To investigate a method to detect the sentinel lymph nodes(SN) of thyroid papillary carcinoma and its predictive value for cervical metastasis of carcinoma. Methods Intraoperative methylene blue dye mapping was performed in 24 cases of thyroid papillary carcinoma. The coincidence rate of frozen section pathology and routine section pathology of SN was observed,and the predictive value of SN for (metastasis) of the cervical lymph nodes was noted. Results SN was successfully detected in 21(87.5%) of 24 cases. The average number of SN was 3 nodes. There was one false negative case, the false negative rate was 4.8%(1/24), and no false positive cases were found. The predictive value of sentinel lymph nodes to (cervical) lymph node metastasis was 83.3%.Conclusions Methylene blue staining to identify sentinel lymph nodes could accurately predict the status of cervical lymph node metastasis of thyroid papillary carcinoma.