| HCMV大小鼠眼组织损伤模型的初步研究 |
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| 引用本文： | 孟红,孙广莲,李焱,刘菊华,王玉梅.HCMV大小鼠眼组织损伤模型的初步研究[J].实验动物与比较医学,2001,21(3):150-151. |
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| 作者姓名： | 孟红 孙广莲 李焱 刘菊华 王玉梅 |
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| 作者单位： | 上海第二医科大学附属新华医院、上海儿童医学中心胸心外科,上海,200127 |
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| 基金项目： | 国家自然科学基金资助项目(39770734) |
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| 摘 要： | 为探讨低温技术在胎羊体外循环中的应用，将12头孕齿120－140d的白山羊随机分为常温组（37℃,n=6)和低温组（28℃,n=6)，建立胎羊体外循环模型，体外转流1h，监测胎羊和母羊的体温、血压、心率和血气值。结果显示，低温转流中胎羊心率减慢，血液PH值下降明显。转流后低温组胎羊较常温组出现更为严重的低氧，高碳酸血症和酸中毒（P＜0．05），血压下降明显，心率减慢，其中2头胎羊心脏停跳。表明胎羊体外循环中低温对胎儿－胎盘单元更为不利。
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| 关 键 词： | 胎羊 低温体外循环 存活率 |
| 文章编号： | 1004-8448(2001)03-0150-04 |
| 修稿时间： | 2000年10月19 |
Study on Eye Disease of Animal Infected with HCMV AD169 Strain |
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| MENG Hong,SUN Guanglian,LI Yan,LIU Juhu,WNAG Yumei.Study on Eye Disease of Animal Infected with HCMV AD169 Strain[J].Laboratory Animal and Comparative Medicine,2001,21(3):150-151. |
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| Authors: | MENG Hong SUN Guanglian LI Yan LIU Juhu WNAG Yumei |
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| Abstract: | Objective To investigate whether HCMV infection can cause ocular tissue lesions in rats and mice.Methods Twenty rats and ten mice were inoculated with HCMV AD 169 strain by vein and development of ocular disease was observed.HCMV DNA of tissues from inoculated animals were examined by in situ hybridization.Results Some animals expressed much secretion,turbidity in eyes even losing sight at different time post\|inoculation.HCMV DNA sections were identified in the corneal endothelium cell,rod cell and cone cell of the rats and mice inoculated. Conclusion HCMV AD 169 strain can infect rats and mice and cause ocular disease. |
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| Keywords: | Fetal lamb Hypothermia Cardiopulmonary bypass |
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