载脂蛋白B、N末端B型脑钠尿肽前体与冠状动脉病变程度的相关性

目的探讨血清载脂蛋白B（apolipoprotein B,ApoB）水平、血清N末端B型脑钠尿肽前体（NTproBNP）与冠状动脉病变程度相关性。方法收集166例心内科门诊患者,根据冠状动脉64排CT的结果分为单支病变组42例、双支血管病变组43例、三支血管病变组41例、冠状动脉正常对照组40例,分析血清ApoB、NT-proBNP水平与冠状动脉狭窄严重程度的相关性。结果单支血管病变组、双支病变组、三支病变组ApoB均低于冠状动脉正常对照组,分别为（1.09±0.21）g/L、（2.00±0.08）g/L、（2.22±1.14）g/L vs（0.75±0.17）g/L（P〈0.01）;单支血管病变组、双支血管病变组和三支血管病变组NT-proBNP均高于冠状动脉正常对照组,分别为（98.70±38.07）ng/L、（233.69±78.53）ng/L、（305.04±131.65）ng/L vs（23.00±8.54）ng/L（P〈0.01）、双支血管病变组和三支血管病变组又高于单支病变组;三支血管病变组又高于双支血管病变组（P〈0.01）,ApoB与冠状动脉病变支数呈正相关（rs=0.130,P〈0.05）,NT-proBNp与冠状动脉病变支数呈正相关（rs=0.118,P〈0.05）。结论随着血清ApoB和NT-proBNP升高,冠状动脉病变越来越严重。

Correlation of apolipoprotein B and N end of B-type natriuretic peptide with severity of coronary artery lesions

Objective To explore serum apolipoprotein B（ApoB）levels,serum levels of N end of B-type natriuretic peptide（NT-proBNP）and the correlation with coronary artery lesion severity.Methods A total of 166 patients from the cardiology clinic were enrolled,according to the result of 64 row CT coronary artery,the patients were divided into single branch lesion group 42 cases,double branch lesion group 43 cases,three branch lesions group 41 cases,coronary artery normal control group 40 cases.Analysis was conducted on serum ApoB levels,NT-proBNP and their correlation with the severity of coronary artery stenosis.Results ApoB of single vascular lesion,double branch lesion,three branch lesion group were significantly lower than that of coronary artery normal control group,respectively（1.09±0.21）g/L,（2.00±0.08）g/L,（2.22±1.14）g/L vs（0.75±0.17）g/L（P 0.01）.NT-proBNP of single branch lesion,double branch lesion,three branch lesion group were significantly higher than that of coronary artery normal control group,respective,（98.70±38.07）ng/L,（233.69±78.53）ng/L,（305.04±131.65）ng/L vs（23.00±8.54）ng/L（P 0.01）,NT-proBNP of the double branch lesion group and three branch lesion group were higher than that of single branch lesion;NT-proBNP of three branch lesion group was higher than that of the double branch lesion（P 0.01）.Positive correlation existed between coronary artery lesion counts and ApoB（rs=0.130,P0.05）,NTproBNP and coronary artery lesion counts were positively correlated（rs=0.118,P 0.05）.Conclusion With serum ApoB and NT-proBNP increase,more and more serious coronary artery disease appears.