Antibodies to the Human T-Cell Lymphoma/Leukemia Virus Type I in Dutch Haemophiliacs |
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| Authors: | Jaap Goudsmit Frank Miedemca Cees Breederveld Fokke Terpstra Marijke Roos Peter Schellekens and Cees Melief |
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| Affiliation: | Virology Department, Academic Medical Centre of the University of Amsterdam, Amsterdam;Central Laboratory of the Netherlands' Red Cross Blood Transfusion Service, Amsterdam;Pediatrics Department, Academic Medical Centre of the University of Amsterdam, The Netherlands |
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| Abstract: | 95 Dutch haemophiliacs were tested for antibodies to membrane antigens on cells infected with human T-cell leukemia virus type I (HTLV-I-MA) by indirect immunofluorescence and to purified HTLV-I by enzyme-linked immunosorbent assay. Antibodies to HTLV-I-MA were present in 8 of 95 (8%) haemophiliacs, but only 3 (3%) had antibodies to purified HTLV-I. No clinical disease was related to HTLV-I seropositivity. The importance of iatrogenic HTLV-I transmission to haemophiliacs is discussed. |
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