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Amelioration of ketamine-induced working memory deficits by dopamine D1 receptor agonists |
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| Authors: | Brooke M. Roberts Patricia A. Seymour Christopher J. Schmidt Graham V. Williams Stacy A. Castner |
| Affiliation: | (1) Department of Psychiatry, Yale University School of Medicine, 300 George Street, Suite 901, New Haven, CT 06511, USA;(2) VA Connecticut Healthcare System, 950 Campbell Ave, West Haven, CT 06519, USA;(3) Neuroscience Research Unit, Pfizer Global Research and Development, Groton, CT 06340, USA; |
| Abstract: | RationaleKetamine has been used in humans to model cardinal symptoms of schizophrenia, including working memory impairments and behavioral disorganization. Translational studies with ketamine in nonhuman primates promise to extend the neurobiological understanding of this model. |
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