| 盐酸西布曲明的合成 |
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| 引用本文： | 李家明,李丰,查大俊.盐酸西布曲明的合成[J].华西药学杂志,2001,16(2):114-115. |
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| 作者姓名： | 李家明 李丰 查大俊 |
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| 作者单位： | 1. 安徽中医学院药化教研室,
2. 合肥医工医药研究所, |
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| 摘 要： | 目的：研究盐酸西布曲明的合成方法。方法：以对氯氰苄为起始原料经环合、格氏反应、还原、氮上的氮甲基化、成盐５步反应合成盐酸西布曲明，并对反应的条件进行了优化。结果：经５步反应合成盐酸西布曲明，总收率为４０．６％。结论：反应条件温和，工艺简便，收率较高，适用于工业化生产。
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| 关 键 词： | 盐酸西布曲明 减肥药 合成 |
| 文章编号： | 1006-0103(2001)02-0114-02 |
| 修稿时间： | 2000年9月1日 |
SYNTHESIS OF SIBUTRAMINE HYDROCHLORIDE |
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| LI Jia-ming,LI Feng,ZHA Da-jun.SYNTHESIS OF SIBUTRAMINE HYDROCHLORIDE[J].West China Journal of Pharmaceutical Sciences,2001,16(2):114-115. |
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| Authors: | LI Jia-ming LI Feng ZHA Da-jun |
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| Abstract: | OBJECTIVE:To study the synthesis of sibutramine hydrochloride METHODS:Sibutramine hydrochloride was synthesized from the starting material 4 chlorobenzylcyanide by cyclization,Grignard reaction,reduction,methylation to afford sibutramine which followed by salt formation with hydrochloride,the conditions in synthesis were improved RESULTS:Sibutramine hydrochloride was synthesized from 4 chlorobenzylcyanide The overall yield was 40 6% CONCLUSION:The methed was more suitable for mass manufacture |
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| Keywords: | Sibutramine hydrochloride Antiobesity agent Synthesis |
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