小剂量灭活卡介苗对慢性阻塞性肺病肺气虚患者细胞免疫功能的影响

为了解小剂量灭活卡介苗对慢性阻塞性肺病（简称慢阻肺）肺气虚患者细胞免疫功能的影响，对小剂量灭活卡介苗治疗（０．５年）前后细胞免疫功能进行了观察。结果表明，慢阻肺肺气虚患者５４例外周血Ｔ淋巴细胞亚群（ＣＤ３、ＣＤ４、ＣＤ８、ＣＤ４／ＣＤ８）及淋巴细胞转化率均明显低于健康人组（Ｐ＜０．０１）；经小剂量灭活卡介苗治疗０．５年后，其Ｔ淋巴细胞亚群及淋巴细胞转化率明显改善（Ｐ＜０．０１或Ｐ＜０．０５）。表明小剂量灭活卡介苗能调节已被减弱的细胞免疫功能。

The Effects of Small Dosage Inactivated BCG Vaccine on Cellular Immune Function of Pulmonary Chronic Obstructive Disease Patients with Deficiency of Lung-Qi

To investigate the effects of the small dosage inactivated BCG vaccine on the cellular immune function of the patients suffered from pulmonary chronic obstructive disease with deficiency of the Lung-Qi,the authors observed the patients,immune function before and after BCG treatment for half a year.Results:The peripheral blood T lymphocytes subsefs(CD3,CD4 CD8,CD4/CD 8) and the conversion ratio of lymphocyte of the patients both were significantly lower than those of the healthy people(P<0.01).But after the treatment of the small dosage inactivated BCG vaccine for half a year,these parameters of the patients were improved(P<0.01 or P<0.05).It indicated that the small dosage inactivated BCG vaccine could improve the damaged cellular immune function.