Systemic lupus erythematosus and vaccination |
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| Authors: | Arnaud Millet Olivier Decaux Antoinette Perlat Bernard Grosbois Patrick Jego |
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| Institution: | 1. UMR 1027, INSERM, Faculté de Médecine, Université de Toulouse III, Toulouse, France;2. Service de Médecine Interne, Centre Hospitalier Universitaire de Toulouse, Toulouse, France;3. CIC 1436, Centre Hospitalier Universitaire de Toulouse, Toulouse, France;4. Service de Médecine Interne et Immunopathologie clinique, Centre Hospitalier Universitaire de Toulouse, Toulouse, France;5. Département d''Information Médicale, Centre Hospitalier Universitaire de Toulouse, Toulouse, France;6. Service de Pharmacologie Médicale et Clinique, Faculté de Médecine, Centre Hospitalier Universitaire de Toulouse, Toulouse, France |
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| Abstract: | Patients with systemic lupus erythematosus (SLE) are frequently immunodepressed making them more vulnerable to infections. Preventive vaccination is therefore warranted but has often been withheld owing to fears of a link between infection and autoimmunity, and the possibility of inducing or exacerbating lupus after vaccination. The data published in the literature suggest that vaccination of lupus patient is safe, except for live vaccines. Their efficacy is lower than in healthy subjects but protection seems to be sufficient. But further large-scale studies are required to confirm these statements. |
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