桥本甲状腺炎实时超声弹性成像评分与自身免疫的相关性探讨

目的:探讨桥本甲状腺炎(HT)超声弹性评分和弹性系数与甲状腺自身免疫功能的相关性。方法:216 例桥本甲状腺炎患者,采用GE LOGIQ3 型彩色多普勒超声诊断仪获得满意弹性图像后,评定弹性评分及弹性系数;化学发光法检测甲状腺功能及甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TgAb) 滴度,分别分析甲状腺超声弹性评分和弹性系数与甲状腺自身抗体相关性。结果:216 例HT 患者血清促甲状腺激素(TSH)、TGA、TPO 明显升高,TgAb 的滴度与弹性系数呈正相关,r=0.54,P<0.01;TgAb 与弹性评分呈正相关,r =0.496,P<0.01;TPOAb 与弹性应变系数呈正相关,r =0.77,P<0.01,TPOAb 与弹性评分呈正相关,r =0.73,P<0.01。结论:实时超声弹性成像评分结合甲状腺自身免疫功能检测,有助于提高桥本甲状腺炎诊断的正确性。

Investigation of correlation between real-time ultrasound elastosonography score and autoimmunity in patients with hashimoto thyroiditis

 Objective:To investigate the correlation between ultrasonic elasticity score,elasticity coefficient and autoimmune thyroid function in patients with HT(hashimoto thyroiditis).Methods: Used GE LOGIQ3 type Color Doppler Ultrasound Diagnostic System to acquire satisfactory elastosonography from 216 patients with HT,and evaluated the elasticity score and elasticity coefficient;to detecte the thyroid function and the titer of Thyroid peroxidase antibody ( TPOAb), Thyroid globulin antibody ( TgAb) by chemiluminescence,respectively investigated the correlation between ultrasonic elasticity score,elasticity coefficient and autoimmune thyroid function.Results: Serum Thyroid stimulating hormone(TSH),TGA and TPO in 216 patients with HT increased significantly,TgAb and elastic coefficient were positively correlated,r = 0.54,P <0.01;TgAb and elasticity score were positively correlated,r =0.496,P<0.01;TPOAb and elastic coefficient were positively correlated,r =0.77,P<0.01,TPOAb and elasticity score were positively correlated,r =0.73,P<0.01.Conclusion: Real-time ultrasound elastography in combination with measurement of autoimmune thyroid function was helpful to diagnosis of HT.