纳米药物递送系统在结核病治疗中的研究进展

目前,结核病防治形势仍十分严峻。然而,传统抗结核药物治疗方案存在疗程长、药物不良反应多以及患者依从性差等问题,常导致治疗失败,故亟需可以控制结核病的新药或新剂型。装载抗结核药物的纳米药物递送系统可以将抗结核药物主动或被动靶向到被感染的细胞或病灶部位内,杀菌的同时,还具有缓释给药、减少给药频率、减少剂量依赖性不良反应等优势。本文综述了纳米递药系统在结核病治疗方面的应用情况及前景。

Recent progress of Nano-drug delivery system for tuberculosis treatment

At present, the prevention and control of tuberculosis are still severe. However, the conventional anti-tuberculosis drug regimens have several limitations such as a long course of treatment, high incidence of adverse reactions, and poor patient compliance, which often lead to treatment failures. Therefore, there is an urgent need for new drugs or new dosage forms that can control tuberculosis. The nano-drug delivery system loaded with anti-tuberculosis drugs can actively or passively deliver drugs into infected macrophages or focal sites for sterilization, and it also have advantages of sustained-release administration, reducing dosing frequency and dose-dependent adverse reactions. etc. This article reviews the application and prospect of nano-drug delivery systems in the treatment of tuberculosis.