| 定量磁化率成像在孤独症儿童脑铁含量的应用研究 |
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| 引用本文： | 程卓,唐世龙,周瑜,何玲,戴春梅,吴兰,刘先凡. 定量磁化率成像在孤独症儿童脑铁含量的应用研究[J]. 中国临床医学影像杂志, 2022, 0(2): 77-81 |
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| 作者姓名： | 程卓 唐世龙 周瑜 何玲 戴春梅 吴兰 刘先凡 |
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| 作者单位： | 重庆医科大学附属儿童医院放射科国家儿童健康与疾病临床医学研究中心;儿科学重庆市重点实验室;儿童发育疾病研究教育部重点实验室 |
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| 基金项目： | 国家儿童健康与疾病临床医学研究中心临床医学研究青年项目(NO.NCRCCHD-2021-YP-07);重庆市教育委员会(NO.KJQN202000425)。 |
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| 摘 要： | 目的:探讨定量磁化率成像在孤独症儿童脑铁含量的应用.方法:对照组,前瞻性选取2018年6—12月2～3岁、3～4岁年龄段正常儿童各40名;研究组,前瞻性选取2019年1月—2020年10月2～3岁、3～4岁年龄段孤独症儿童各40名;所有儿童均行头部MRI常规扫描和增强T2*加权磁共振血管造影(ESWAN)序列扫描,通过...
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| 关 键 词： | 孤独性障碍 磁共振成像 铁 |
The application of quantitative susceptibility mapping in the brain iron content of autistic children |
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| CHENG Zhuo,TANG Shi-long,ZHOU Yu,HE Ling,DAI Chun-mei,WU Lan,LIU Xian-fan. The application of quantitative susceptibility mapping in the brain iron content of autistic children[J]. Journal of China Clinic Medical Imaging, 2022, 0(2): 77-81 |
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| Authors: | CHENG Zhuo TANG Shi-long ZHOU Yu HE Ling DAI Chun-mei WU Lan LIU Xian-fan |
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| Affiliation: | (Department of Radiology,Children’s Hospital of Chongqing Medical University,National Clinical Research Center for Child Health and Disorders,Chongqing 400014,China;Chongqing Key Laboratory of Pediatrics,Chongqing 400014,China;Ministry of Education Key Laboratory of Child Development and Disorders,Chongqing 400014,China) |
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| Abstract: | Objective:To invest igate the app lication of quantitative susceptibility mapping in the brain iron content of autistic children.Methods:Forty normal children aged 2~3 and 3~4 years old from June to December 2018 were prospectively selected as the control group.Forty autistic children aged 2~3 and 3~4 years old from January 2019 to October 2020 were prospectively selected as the study group.All children underwent routine head MRI scanning and enhanced T2*-weighted magnetic resonance angiography(ESWAN)sequence scanning,and ESWAN sequence images were processed by software to obtain magnetic susceptibility map.The regions of interest of bilateral frontal gray and white matter,caudate nucleus,globus pallidus,thalamus,putamen,red nucleus,substantia nigra,pons,dentate nucleus,and splenium of corpus callosum were manually delineated and the magnetic susceptibility values were obtained.The difference of brain magnetic susceptibility between two groups at the same age was compared.Results:In the 2~3 years old group,the magnetic susceptibility values of various parts of the brain in the study group were lower than those in the control group(P<0.05),the magnetic susceptibility values of caudate nucleus,dentate nucleus and splenium of corpus callosum in the study group were lower than those in the control group(P<0.05).In the 3~4 years old group,the magnetic susceptibility values of various parts of the brain in the study group were lower than those in the control group(P<0.05),the magnetic susceptibility values of frontal white matter,caudate nucleus,red nucleus,substantia nigra,dentate nucleus and splenium of corpus callosum in the study group were lower than those in the control group(P<0.05).Conclusion:The content of iron in the brain of autistic children is lower than that of normal children,which has clinical significance. |
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| Keywords: | Autistic Disorder Magnetic Resonance Imaging Iron |
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