宫颈高级别鳞状上皮内病变合并原位腺癌临床病理分析(附5例)

目的:探讨宫颈高级别鳞状上皮内病变合并原位腺癌的临床病理特征、诊断与鉴别诊断.方法:复习5例宫颈高级别鳞状上皮内病变合并原位腺癌的临床病理资料,并结合国内外文献讨论分析.结果:宫颈高级别鳞状上皮内病变合并原位腺癌好发于中年女性;镜下病变具备高级别鳞状上皮内病变和原位腺癌两部分组织学特征,两种肿瘤成分界限清楚、相互独立....

A clinicopathological analysis of high-grade squamous intraepithelial lesion and adenocarcinoma in situ of the uterine cervix(5 cases)

Objective:To study the clinicopathological features,diagnosis and differential diagnosis of high-grade squamous intraepithelial lesion and adenocarcinoma in situ of the uterine cervix.Methods:Five patients with high-grade squamous intraepithelial lesion and adenocarcinoma in situ of the uterine cervix were reviewed retrospectively.Related domestic and foreign literatures were analyzed and discussed.Results:High-grade squamous intraepithelial lesion and adenocarcinoma in situ of the uterine cervix occurred among middle-aged women.High-grade squamous intraepithelial lesion and adenocarcinoma in situ had different histopathology.They were independent lesion.The results showed that both high-grade squamous intraepithelial lesion and adenocarcinoma in situ had diffuse nuclear and cytoplasmic immunohistochemical staining with p16.Both high-grade squamous intraepithelial lesion and adenocarcinoma in situ had increased Ki-67 expression.Adenocarcinoma in situ showed cytoplasmic positivity for CEA.Three cases performed HPV detection in five patients.One case was positive for HPV16.Two cases were positive for HPV18.Conclusion:Because of the coexistence of two lesions,high-grade squamous intraepithelial lesion and adenocarcinoma in situ of the uterine cervix is easy to be misdiagnosed.HPV16 and HPV18 demonstrate the carcinogenic potency in high-grade squamous intraepithelial lesion and adenocarcinoma in situ of the uterine cervix.