降钙素原水平与维持性血液透析患者全因死亡的关系

目的 探讨降钙素原(PCT)水平与维持性血液透析(MHD)患者全因死亡的关系.方法 选取MHD患者160例,收集其临床资料,包括性别、年龄、体质量指数(BMI)、吸烟史、原发疾病、合并症、透析时间、纽约心脏病学会(NYHA)心功能分级和实验室指标检测结果.采用受试者工作特征(ROC)曲线得出各项指标区分MHD患者死亡与...

Relationship between procalcitonin level and all-cause death in maintenance hemodialysis patients

Objective To investigate the relationship between procalcitonin(PCT)level and all-cause death in patients undergoing maintenance hemodialysis(MHD).Methods A total of 160 patients undergoing MHD were enrolled,and their clinical data,including sex,age,body mass index(BMI),smoking history,primary disease,comorbidities,dialysis duration,New York Heart Association(NYHA)cardiac function classification and laboratory indicators,were collected.Receiver operating characteristic(ROC)curve was used to determine the optimal cut-off value of death and survival in MHD patients.The patients with PCT>optimal cut-off value were taken as high PCT group,and those with PCT≤optimal cut-off value were taken as low PCT group.The influencing factors of high PCT were analyzed by binary Logistic regression.Kaplan-Meier survival curve was used to analyze the survival rate of MHD patients.Cox proportional risk regression analysis was used to evaluate the relationship between PCT and all-cause death in MHD patients.Results The dialysis duration and CRP levels in high PCT group were higher than those in low PCT group(P<0.01),but there was no statistical significance for the other indicators(P>0.05).Binary Logistic regression analysis showed that increased CRP level was a risk factor for high PCTodds ratio(OR)=1.182,95%confidence interval(CI)1.043-1.339,P=0.009].Kaplan-Meier survival curve analysis showed that the survival rate of high PCT group was lower than that of low PCT group(Log-rankχ²=6.707,P=0.01;Breslow test value was 6.828,P=0.009).Cox proportional risk regression analysis showed that high triglyceride(TG)level was a protective factor for all-cause death in MHD patientshazard ratio(HR)=0.166,95%CI 0.071-0.387].High PCT level was a risk factor for all-cause death in MHD patients(HR=4.409,95%CI 1.757-11.064).Conclusions High PCT level may be an independent risk factor for all-cause death in MHD patients.