| 限量饮食对黄曲霉素B_1-DNA加合物生成的影响 |
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| 引用本文： | 陈雯,张桥,吴中亮,周明武.限量饮食对黄曲霉素B_1-DNA加合物生成的影响[J].癌变．畸变．突变,1997(5). |
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| 作者姓名： | 陈雯 张桥 吴中亮 周明武 |
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| 作者单位： | 中山医科大学卫生毒理学教研室，广州医学院化学致癌研究所，美国国家毒理研究中心 |
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| 摘 要： | 本实验用黄曲霉毒素Ｂ１（ＡｆｌａｔｏｘｉｎＢ１，ＡＦＢ１）作为致癌物代表，研究限量饮食（Ｆｏｏｄｒｅｓｔｒｉｃｔｉｏｎ，ＦＲ）对雄性Ｆ３４４大鼠和Ｂ６Ｃ３Ｆ１小鼠代谢活化ＡＦＢ１的影响。ＡＦＢ１－ＤＮＡ加合物（ＡＤＡ）作为ＡＦＢ１代谢活化的生物指标。结果显示ＦＲ降低大鼠和小鼠对ＡＦＢ１的代谢活化，ＡＤＡ的生成在大鼠和小鼠中分别减少４３％和３１％。ＡＤＡ的两种主要加合物的生成、分布和清除以及它们与ＡＦＢ１致癌作用的关系也作了讨论。
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| 关 键 词： | 限量饮食 AFB_1代谢活化 AFB_1-DNA加合物 |
EFFECT OF FOOD RESTRICTION ON AFLATOXIN B 1 DNA ADDUCT FORMATION |
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| Abstract: | Using aflatoxin B 1(AFB 1) as a model carcinogen,we have studied the effect of food restriction (FR) on the metabolic activation of AFB 1 in male Fischer 344 rats and B6C3F 1 mice.AFB 1 DNA adduct(ADA) was used as a biomarker of the metabolic activation of AFB 1.The results showed that FR reduced the metabolic activation of AFB 1 in both rats and mice,causing the formation of ADA to decrease 43% and 31%,respectively.The formation,distribution and the removal of the two major ADAs,AFB 1 N 7 Gua and AFB 1 FAP in mice were measured.The correlation of the two ADAs with AFB 1 induced carcinogenesis was also discussed. |
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| Keywords: | Food restriction Metabolic activation AFB 1 DNA adduct |
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