| 静脉输注维生素E对大鼠急性胆管炎时肝脏功能的保护作用 |
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| 引用本文： | 李昆,韩本立,段恒春,陈莉. 静脉输注维生素E对大鼠急性胆管炎时肝脏功能的保护作用[J]. 中国普外基础与临床杂志, 1999, 6(2): 68-69 |
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| 作者姓名： | 李昆 韩本立 段恒春 陈莉 |
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| 作者单位： | 第三军医大学西南医院肝胆外科中心,重庆,400038 |
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| 摘 要： | 为观察急性胆管炎时脂质过氧化损害情况，以及维生素Ｅ（ＶＥ）乳剂对肝功能的保护作用，采用大鼠急性胆管炎模型，于模型和时及制作后２４小时膜静脉注入ＶＥ乳剂或空白乳剂，并于制作后４８小时活杀动物，取肝脏组织及血清检测丙二醛含量，超氧化物歧化酶活性及三磷酸腺苷含量。结果；与空白乳剂组比较，ＶＥ乳剂组肝组织及血清中ＭＤＡ和线粒体谷草转氨酶均显著降低，ＳＯＤ活性显著升高；感染肝叶肝脏组织ＡＴＰ含量亦显著高于空
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| 关 键 词： | 急性 胆管炎 脂质过氧化 维生素E 肝功能 |
THE PROTECTING EFFECT OF VITAMIN E ON LIVER FUNCTION FOLLOWING ACUTE CHOLANGITIS |
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| Li Kun,Han Benli,Duan Hengchun,et al.. THE PROTECTING EFFECT OF VITAMIN E ON LIVER FUNCTION FOLLOWING ACUTE CHOLANGITIS[J]. Chinese Journal of Bases and Clinics In General Surgery, 1999, 6(2): 68-69 |
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| Authors: | Li Kun Han Benli Duan Hengchun et al. |
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| Affiliation: | Li Kun,Han Benli,Duan Hengchun,et al. Center of Hepatobiliary Surgery,Southwest Hospital,Third Military Medical University,Chongqing 400038 |
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| Abstract: | To study the lipid peroxidation injury and the protecting effect of vitamin E emulsion on liver function following acute cholangitis. During the operation and 24 hours after operation, vitamin E emulsion or placebo emulsion was infused via mesenteric vein in rats suffering acute cholangitis. The contents of malondialdehyde (MDA), superoxide dismutase (SOD) and adenosine triphosphate (ATP) in the liver tissue and serum were measured at 48hrs after operation. Results: As compared with the placebo emulsion group, MDA and m GOT contents in the liver tissue and serum decreased significantly, but SOD activity increased dramatically in the VE emulsion group. ATP content in the infected lobe was much higher than those in the placebo emulsion group. Conclusion: Intravenous infusion of large dose of vitamin E emulsion may reduce the lipid peroxidation reaction in acute cholangitis, and have protecting effect. |
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| Keywords: | Acute cholangitis Lipid peroxidation Vitamin E |
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