Rationale and Design of the Multicenter Trial on Japan Working Group on the Effects of Angiotensin Receptor Blockers Selection (Azilsartan vs. Candesartan) on Diastolic Function in the Patients Suffering from Heart Failure with Preserved Ejection Fraction: J-TASTE Trial |
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| Authors: | Hiroyuki?Takahama Masanori?Asakura Yukio?Abe Masayoshi?Ajioka Kazutaka?Aonuma Toshihisa?Anzai Takaharu?Hayashi Shinya?Hiramitsu Hiroya?Kawai Hidetaka?Kioka Kazuo?Kimura Young-Jae?Lim Ken?Matsuoka Hirohiko?Motoki Yoji?Nagata Sunao?Nakamura Nobuyuki?Ohte Yukio?Ozaki Taishi?Sasaoka Shunsuke?Tamaki Toshimitsu?Hamasaki Masafumi?Kitakaze |
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| Affiliation: | 1.Department of Cardiovascular Medicine,National Cerebral and Cardiovascular Center,Suita,Japan;2.Department of Clinical Medicine and Development,National Cerebral and Cardiovascular Center,Suita,Japan;3.Hyogo Medical College,Nishinomiya,Japan;4.Osaka City General Hospital,Osaka,Japan;5.Tosei Hospital,Seto,Japan;6.Tsukuba University Medical School,Tsukuba,Japan;7.Hokkaido University Graduate School of Medicine,Sapporo,Japan;8.Osaka Police Hospital,Osaka,Japan;9.Hiramitsu Heart Clinic,Nagoya,Japan;10.Hyogo Brain and Heart Center at Himeji,Himeji,Japan;11.Osaka University Graduate School of Medicine,Suita,Japan;12.Cardiovascular Center,Yokohama City University General Medical Center,Yokohama,Japan;13.Kawachi General Hospital,Higashi-Osaka,Japan;14.Yoshikawa Hospital,Sakai,Japan;15.Shinshu University School of Medicine,Matsumoto,Japan;16.Kanazawa University Graduate School of Medicine,Kanazawa,Japan;17.Shin-Tokyo Heart Clinic,Matsudo,Japan;18.Nagoya City University Graduate School of Medical Sciences,Nagoya,Japan;19.Fujita Health University School of Medicine,Toyoake,Japan;20.Wanabe Hospital,Okegawa,Japan;21.Osaka General Medical Center,Osaka,Japan;22.Department of Data Science, Department of Advanced Medical Technology Development,National Cerebral and Cardiovascular Center,Suita,Japan |
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| Abstract: | BackgroundPrevious studies suggest that the pathophysiology of heart failure with preserved ejection fraction (HFpEF) is characterized not only by high ventricular stiffness, but also by vascular stiffness. Azilsartan has higher vascular affinity compared with other angiotensin II receptor blockers (ARBs), which were proven to have no beneficial effects on clinical outcomes in patients with HFpEF in earlier clinical trials. We aimed to test the hypothesis that azilsartan may improve left ventricular diastolic function in HFpEF patients with hypertension in this trial.MethodsThe Effects of Angiotensin Receptor Blockers on Diastolic Function in Patients Suffering from Heart Failure with Preserved Ejection Fraction: J-TASTE trial is a multicenter, randomized, open-labeled, and assessor(s)-blinded, active controlled using candesartan, parallel-group clinical trial, to compare changes in left ventricular (LV) diastolic dysfunction between HFpEF patients with hypertension who have received candesartan or azilsartan for 48 weeks. The primary endpoint is the change in early diastolic wave height/early diastolic mitral annulus velocity (E/e’) assessed by echocardiography from the baseline to the end of the study (48 weeks). A total of 190 patients will be recruited into the study.ConclusionsThe design of the J-TASTE trial will provide data on whether differences between the effects of the two tested drugs on LV diastolic function exist in HFpEF patients with hypertension and will improve understanding of the pathophysiological role of vascular stiffness on diastolic function. |
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