复方丹参对动物耐缺氧和心脏血流动力学的研究

腹腔注射复方丹参20 g/kg,可显著延长小鼠在常压缺氧情况下的存活时间,作用持续时间达3小时以上。腹腔注射10～20 g/kg,可显著延长小鼠在低压缺氧条件下的存活时间和提高存活率。腹腔注射5 g/kg,也能显著延长大鼠在低压缺氧的存活时间。胍乙啶的初和晚时相,均可降低小鼠对低压缺氧的耐受力,而复方丹参只能提高晚时相所降低的耐缺氧能力。腹腔注射复方丹参30 g/kg,显著延长常压缺氧的存活时间和减慢小鼠氧耗速率,死亡时余存氧含量亦较对照组显著减低,表明复方丹参可能是提高小鼠在低氧状态下对氧的利用。复方丹参浓度为10 mg/ml,显著增加离体豚鼠心脏的冠脉流量,但不增加颤动心脏的冠脉流量。静注复方丹参4g/kg,不增加大鼠心肌摄取~(86)Rb率,表明不增加心肌血流量。麻醉开胸狗,静注复方丹参1 g/kg,对冠脉流量和冠脉阻力无明显作用。麻醉狗静注复方丹参0.75 g/kg,对心脏血流动力作用也无明显影响。

STNDIES ON TOLERANCE TOWARD HYPOXIA AND CARDIAC HEMODYNAMICS OF SALVIA MILTIORRHZA COMPOSITA IN ANIMALS

Injectio Salvia miltiorrhizae Composita is composed of 1:1 extracts of Salvia miltiorrhiza and Dalbergia odorifera.The intraperitoneal injections (ip) of 20 g/kg of this composita prolonged significantly the survival time of the mice under normobaric hypoxia, and this protective effect lasted at least 3 hours. The ip of 10～20 g/kg resulted in a prolongation of survival time and an elevation of survival % of the mice under hypobaric hypoxia. The ip of 5 g/kg also lengthened notably the survival time of rats. Guanethidine, in both initial and late phases of its action, lowered the tolerance towards the hypobaric hypoxia of mice, whereas this composita could restore the tolerance only in the late phase of guanethidine action. After ip 30 g/kg in mice, the O₂ consumption rate was slowed down in normobaric hypoxia, and the survival time was prolonged remarkably which decreased the residual O₂ content more than the control mice at the time of death. It is suggested that this composita might improve the O₂ utilization during hypoxia.In the concentration of 10 mg/ml this composita enhanced markedly the coronary flow on isolated guinea pig hearts, but not on fibrillating hearts. When this coinposita was given intravenously (ⅳ) 4 g/kg, the % of myocardial uptake of ~(86)Rb was not raised in rats. This indicates that the myocardial blood flow was not augmented.In anesthetized open-chest dogs, the ⅳ of 1 g/kg produced no marked alteration of coronary blood flow and coronary resistance. The ⅳ injection of 0.75g/kg did not yield remarkable influence on cardiac hemodynamic results either.