某地区不同肥胖分型学龄儿童外周血炎性细胞因子表达的分析

目的分析沈阳地区不同肥胖分型学龄儿童外周血炎性细胞因子表达水平。方法连续选择近期来我院诊治的肥胖学龄儿童57例(腹型肥胖22例,复合型肥胖18例和外周型肥胖17例),对照组选择同期参加体检、且结论健康儿童19例,两组对象均接受了外周血炎性细胞因子[高敏C-反应蛋白(Hs-CRP)、肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)和白细胞介素-8(IL-8)]表达水平检测。结果不同肥胖分型学龄儿童外周血Hs-CRP、TNF-α、IL-6和IL-8表达水平均明显高于对照组(P均<0.05~0.01)。同时,腹型肥胖组外周血Hs-CRP、TNF-α、IL-6和IL-8表达水平表达水平也显著高于复合型和外周型肥胖学龄儿童(P均<0.05~0.01)。结论沈阳地区不同肥胖分型学龄儿童存在着明确的外周血炎性细胞因子高水平表达,且以腹型肥胖组最为突出。

Analysis of Peripheral Inflammatory Cytokines among School Children with Different Obesity Types in A City

Objective To analyze the expressions of peripheral inflammatory cytokines among school children with different obesity types in Shenyang city.Methods A total of 57 school children with obesity,including abdominal obesity（n=22）,combined obesity（n=18） and peripheral obesity（n=17）,and other 19 healthy children as control group were selected to treat with test of peripheral inflammatory cytokines,i.e.,high-sensitive C-reactive protein（HS-CRP）,tumor necrosis factor-α（TNF-α）,interleukin 6（IL-6）,and interleukin 8（IL-8）.Results The expressions of HS-CRP,TNF-α,IL-6 and IL-8 in the obesity group were significantly higher than those in the control group（P0.05-0.01）.Meanwhile,the expressions of HS-CRP,TNF-α,IL-6 and IL-8 in abdominal obesity group were significantly higher than those in the combined and peripheral obesity groups（P0.05-0.01）.Conclusion The expressions of peripheral inflammatory cytokines were high in obesity children,especially in abdominal obesity children.