T-Lymphoblasts with Erythropoietic Helper Function in Acute T-Cell Leukemia |
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Authors: | Jonathan L. Finlay Dorothy J. Ganick Nasrollah Shahidi Wayne Borcherding Richard Hong Paul Sondel |
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Affiliation: | a Department of Pediatrics, Divisions of Hematology/Oncology and Immunology, University of Wisconsin Center for Health Sciences, Madison, Wisconsin |
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Abstract: | A patient with acute T-lymphoblastic leukemia was found to maintain a normal hemoglobin concentration both at presentation and preterminally several months later, despite a replaced bone marrow and over 80% circulating lymphoblasts on both occasions. Cell surface marker analysis demonstrated the T-lymphoblasts both at presentation and preterminally to belong to the T-helper subpopulation. In vitro culture studies demonstrated that the patient's T-lymphoblasts, as well as conditioned medium derived from these lymphoblasts, significantly stimulated normal bone marrow erythroid colony growth (CFU-E). These findings suggest that in this patient the preservation of erythropoiesis resulted from a helper effect exerted by his T-lymphoblasts. |
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Keywords: | T-lymphoblasts acute leukemia erythropoiesis |
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