肾综合征出血热病毒宫内感染的临床研究

目的 研究肾综合征出血热(HFRS)病毒宫内感染情况及其对婴儿的影响。方法 对妊娠期感染HFRS病毒者，于其分娩时留取母血和脐带血进行抗—HFRS IgG检测，同时对顺产新生儿采取静脉血进行抗—HFRS IgM检测，并应用血凝抑制试验(HI)对HFRS病毒进行分型，另外对顺产的新生儿进行全面查体和定期随访观察。结果 母血抗—HFRS IgG均阳性，死胎的27例脐带血抗—HFRS IgG阳性23例，孕妇痊愈后自然分娩的12例中脐带血和静脉血有2例抗—HFRS IgG阳性，而抗—HFRS IgM阴性。并发现14例顺产新生儿生长发育全部正常。结论 HFRS病毒存在宫内感染，并易致死胎，但对顺产婴儿未发现致畸作用。

Clinical study on intrauterine hemorrhagic fever with renal syndrome virus infection

Objective To find out the status of intrauterine infection with hemorrhagic fever with renal syndrome virus (HFRSV).Methods The blood of mothers and the umbilical cords were examined by using anti HFRSV IgG at labor of mothers infected with HFRSV.The venous blood of naturally delivered babies were examined for anti HFRSV IgM, HI test was used to type the HFRSV.Results Mothers blood showed positive reaction for anti HFRSV IgG. Twenty three of 27 cases of the fetal death were umbilical cords blood positive;two out of twelve of umbilical cord blood that the babies were born naturally after their mothers recovered showed positive for anti HFRSV IgG but negative for anti HFRSV IgM,14 babies born naturally normally. Conclusion HFRSV can cause intrauterine infection,and lead to fetal death,but no post natal deformity was observed in the babies born naturally.