血清NTx和BSP测定在非小细胞肺癌骨转移诊断中的价值

目的探讨骨唾液酸蛋白（BSP）和血清Ⅰ型胶原交联氨基末端肽（NTx）测定在非小细胞肺癌骨转移诊断中的临床意义。方法将67例肺癌患者初诊时分为骨转移组和无骨转移组,其中骨转移组32例,非骨转移组35例,并采用ELISA法对血清中NTx和BSP水平进行检测。初诊后12个月对肺癌患者骨转移情况采用影像学检查进行再次评估。结果与无骨转移组相比,骨转移组血清NTX和BSP含量显著升高（P〈0.01）。10例初诊为无骨转移者在随访过程中新发生骨转移癌。与无骨转移组相比,新发骨转移癌组和初诊骨转移组NTx和BSP含量均显著提高（P〈0.05）。结论血清NTx和BSP可用于非小细胞肺癌骨转移诊断,其含量的增高提示非小细胞肺癌患者可能发生了骨转移,从而有利于早期治疗。

Value of serum NTx and BSP in diagnosing non-small cell lung cancer with bone metastasis

Objective To investigate the clinical significance of bone sialoprotein（BSP） and serum type Ⅰ collagen cross-linked N-terminal peptide（NTx） in diagnosing non-small cell lung cancer with bone metastases.Methods 67 patients with lung cancer patients were divided into bone metastasis（n=32） and those without bone metastasis（n=35）s.BSP and serum NTx levels were detected by using ELISA.The patients with bone metastases of lung cancer were re-evaluated by imaging studies 12 months after newly diagnosed.Results Compared with the group without bone metastasis,NTX and BSP in serum was significantly increased and the group difference was statistically significant（P0.01）.10 patients diagnosed as non-bone metastasis occurred new bone metastases during the follow-up.Compared with the non-bone metastases,NTx and BSP of the patients with new bone metastases and bone metastasis were significantly increased,and there was significant difference between the two groups（P0.05）.Contents of NTx and BSP were increase the patients with bone metastases,compared with the group with newly diagnosed bone metastases.Conclusion NTx and BSP in serum can be used for non-small cell lung cancer with bone metastases.The increase of its content may mean non-small cell lung cancer with bone metastasis,which thus facilitates early treatment.