| 亚麻醉剂氯氨酮对肺手术围术期细胞因子的影响 |
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| 引用本文： | 刘刚,王彩珠,徐宁,陈敏敏,劳燕萍.亚麻醉剂氯氨酮对肺手术围术期细胞因子的影响[J].临床肺科杂志,2011,16(11):1663-1665. |
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| 作者姓名： | 刘刚 王彩珠 徐宁 陈敏敏 劳燕萍 |
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| 作者单位： | 广州市胸科医院,广东广州,510095 |
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| 基金项目： | 广州市医药卫生科技一般引导项目(编号2008-YB-217) |
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| 摘 要： | 目的探讨亚麻醉剂氯氨酮在肺手术围术期对细胞因子产生的影响。方法肺大疱切除修补术的气胸患者40例,均分为氯胺酮组（K组）和对照组（C组）。麻醉后手术前给予K组病人氯胺酮并持续静脉滴注至手术结束,对照组采用生理盐水代替氯氨酮,在手术前、术后4 h、24 h、48 h及72 h分别测定IL-1β、IL-2、IL-6和TNF-α的血清浓度。结果术后24 h、48h、72 h,C组病人IL-2水平显著下降,而在K组IL-2能维持在术前水平。术后4 h C组IL-6分泌增加,与K组相比有统计学意义（P〈0.05）;术后4 h K组TNF-α产生的量与术前相似,而在C组显著增加（P〈0.05）。结论麻醉后手术前给予亚剂量氯氨酮能减弱促炎因子IL-6和TNF-α的产生。
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| 关 键 词： | 氯胺酮 细胞因子 肺手术 |
Effect of sub-anesthetic dose of ketamine on the cytokine production in the perioperative period |
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| LIU Gang,WANG Cai-zhu,XU Ning,et al..Effect of sub-anesthetic dose of ketamine on the cytokine production in the perioperative period[J].Journal of Clinical Pulmonary Medicine,2011,16(11):1663-1665. |
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| Authors: | LIU Gang WANG Cai-zhu XU Ning |
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| Institution: | LIU Gang,WANG Cai-zhu,XU Ning,et al.(Department of Anesthesiology,Guang zhou chest hospital,Guangzhou 510095,China) |
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| Abstract: | Objective To study effect of sub-anesthetic dose of ketamine on the cytokine production in the perioperative period.Methods The patients with pneumothorax,who were given bulla excision repair,were randomly selected 40 patients who were divided into two groups: ketamine group(K group) and control group(C group).The patients in K group were given ketamine by intravenous injection and continuous infusion after induction of anesthetic,before operation until end of the operation.The patients in C group were give... |
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| Keywords: | Ketamine cytokine lung surgery |
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