| DC-CIK联合化疗治疗晚期非小细胞肺癌的近期疗效观察 |
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| 引用本文： | 元建华,彭大为,李建旺.DC-CIK联合化疗治疗晚期非小细胞肺癌的近期疗效观察[J].临床肺科杂志,2011,16(12):1910-1911. |
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| 作者姓名： | 元建华 彭大为 李建旺 |
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| 作者单位： | 海口市人民医院, 海南海口,570208 |
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| 摘 要： | 目的探讨DC-CIK联合化疗及常规化疗治疗晚期NSCLC患者的近期疗效。方法 64例临床确诊的晚期NSCLC患者随机分为两组,治疗组给予DC-CIK联合化疗,对照组给予常规化疗。观察治疗前后细胞免疫指标变化、KPS和疗效,及不良反应。结果治疗组CD 3＋、CD 4＋免疫学指标治疗前后比较,具有显著性差异（P值分别为0.018,0.047）,而CD 8＋、CD 4＋/CD 8＋无显著性差异;对照组CD 3＋、CD 4＋、CD 8＋、CD 4＋/CD 8＋免疫学指标治疗前后比较,无显著性差异。治疗组有效率43.75%,对照组有效率34.38%（P〉0.05）。治疗组KPS有效率84.4%,对照组KPS有效率62.5%（P〈0.05）。结论 DC-CIK联合化疗可明显改善晚期NSCLC患者外周血淋巴细胞亚群水平,能增加患者的临床疗效,提高患者的生活质量。
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| 关 键 词： | 树突状细胞 细胞因子诱导的杀伤细胞 非小细胞肺癌 免疫治疗 |
Clinical effects of administering dendritic cells and cytokine induced killer cells combined with chemotherapy in the treatment of advanced non-small cell lung cancer |
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| YUAN Jian-hua,PENGDa-wei,LI Jian-wang.Clinical effects of administering dendritic cells and cytokine induced killer cells combined with chemotherapy in the treatment of advanced non-small cell lung cancer[J].Journal of Clinical Pulmonary Medicine,2011,16(12):1910-1911. |
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| Authors: | YUAN Jian-hua PENGDa-wei LI Jian-wang |
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| Institution: | YUAN Jian-hua,PENG Da-wei,LI Jian-wang.Haikou Municipal Hospital,Haikou 570208,China |
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| Abstract: | Objective To investigate immediate effects of administering dendritic cells(DC) and cytokine induced killer cells(CIK) combined with chemotherapy in patients with advanced non-small cell lung cancer(NSCLC).Methods Sixty-four advanced NSCLC patients were divided two groups randomly: a control group and an immunotherapy with chemotherapy group.The treatment group received DC and CIK at an interval of 10~14 days after chemotherapy.The control group only received chemotherapy.T lymphocyte subtypes in peripheral... |
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| Keywords: | dendritic cells cytokine induced killer cells non-small cell lung cancer immunotherapy |
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