The levels of monoamines and their metabolites in the brain structures of rats with an experimental anxiodepressive state induced by administration of an inhibitor of dipeptidyl peptidase 4 in the early postnatal period |
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Authors: | E Yu Kushnareva N A Krupina N N Khlebnikova V S Kudrin N N Zolotov G N Kryzhanovskii |
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Institution: | 1.Institute of General Pathology and Pathophysiology,Russian Academy of Medical Sciences,Moscow,Russia;2.Zakusov Institute of Pharmacology,Russian Academy of Medical Sciences,Moscow,Russia;3.Moscow,Russia |
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Abstract: | In a model of an experimental anxiodepressive state induced by postnatal administration of an inhibitor of dipeptidyl peptidase
4 (DPP-4), we studied peculiarities of the turnover of dopamine (DA), noradrenaline (NA), and serotonin (5-HT) in the brain
structures of rats at ages of 1, 3, and 7 months. In males, the major changes in the functional activity of the DA system,
which are related to a decrease in DA turnover according to the HVA/DA ratio, were observed in the striatum. In males at an
age of 7 months, we found an increase in the NA level in the hypothalamus. In females, changes in the state of the DA system
included a decrease in the level of DA and its metabolites in the nucleus accumbens (1 and 3 months), the level of DOPAC in
the hypothalamus (3 months), and the level of DA in the striatum (7 months). At all ages, in the hippocampus of females, we
found an increase in the functional activity of 5-HT, according to the 5-HIAA/5-HT and 5-HIAA level. In the frontal cortex
of females at an age of 3 months we found a decrease in the 5-HIAA/5-HT ratio and an increase in the DOPAC/DA ratio, while
at the age of 7 months, we observed an increase in 5-HT. These changes in the activity of the central monoaminergic systems
may reflect specific features of the functioning of the pathological system of the anxiodepressive state in the CNS that determine
the character of the formation and dynamics of emotional behavioral disturbances of male and female rats. |
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