高原红细胞增多症患者红细胞流变性与红细胞SOD、血浆MDA关系的研究

目的:研究不同海拔高度高原红细胞增多症患者红细胞流变学特性与脂质过氧化的关系。方法:对不同海拔高度(刚察县3300m,甘德县4080m)高原红细胞增多症患者检测了红细胞滤过指数(EFI)、红细胞免疫功能、红细胞超氧化物歧化酶(SOD)和血浆丙二醛(MDA)水平。结果:随着海拔的升高,EFI、红细胞免疫复合物花环率和血浆MDA水平上升,而红细胞C₃b受体花环率和红细胞SOD随之降低;相关分析表明:红细胞SOD与EFI和红细胞免疫复合物花环率呈负相关(P＜0.01);而与红细胞C₃b受体花环率呈正相关;MDA则相反。结论:随着海拔升高,高原红细胞增多症患者机体脂质过氧化反应增强,导致了红细胞变形能力降低。

Relationship between erythrocyte rheological properties and RBC superoxide dismutase,plasma malondialdehyde level in patients with high altitude polycythemia

AIM: To study the relationShip between erythrocyte rheological properties and lipid peroxidation in patients with high altitude polycythemia (HAPC). METHODS: Erythrocyte filtration index (EFI), RBC immune function, RBC superoxide dismutase (RBC - SOD) and plasna malondialdehyde (MDA) in 86 patients with HAPC and 88 healthy subjects at different altitudes (3300 m or 4080 m) were measured.RESULTS: EFI, RBC immune complex flower rate (RBCICFR) and plasma MDA level were increased, RBC - SOD and RBC C3b receptor flower rate (RBC C3b RFR )were decreased in pattenes with HAPC. There were masked difference between HAPC patients and healthy subjects. With increasing altitude, EFI, RBCICFR and plasma MDA level in HAPC patients were in- creased markedly, but RBC - SOD and RBC C3b RFR were decreased obviously. RBC - SOD was in negative corre- laton with EEI and RBCICFR, and positive correlation with RBCC3bRFR.Relationship betWeen plasma MDA level and hove mentioned para - meters were reversed. CONCLUSION: Lipid peroxidation in patients with HAPC were increased with increasing altitudes, which may be an important cause of decreasing erythrocyte deformability.