| 癫痫病人血清与唾液中苯妥英浓度的测定及相关性研究 |
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| 引用本文： | 林中,陈赛贞,杨秀斐,陈红,王爱萍. 癫痫病人血清与唾液中苯妥英浓度的测定及相关性研究[J]. 海峡药学, 2005, 17(3): 144-145 |
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| 作者姓名： | 林中 陈赛贞 杨秀斐 陈红 王爱萍 |
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| 作者单位： | 1. 浙江省温州市第二人民医院,温州,325000
2. 浙江省台州医院,台州,317000 |
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| 摘 要： | 目的测定癫痫病人血清与唾液中苯妥英的浓度,总结其相关性。方法采集55例癫痫病人的血清与唾液标本,采用荧光偏振免疫法测定血清、唾液中苯妥英的浓度。结果苯妥英的唾液浓度与血清浓度的平均比值为10.42%±1.1%。结论苯妥英在血清与唾液中的浓度有良好的相关性,相当于血液中游离状态的苯妥英浓度,而且测定唾液浓度的方法取样简便、无创伤,因此更有临床意义。
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| 关 键 词： | 苯妥英 血液 唾液 浓度 相关性 |
| 文章编号： | 1006-3765(2005)03-0144-02 |
Monitoring the Concentration of Phenytoin in Serum,Saliva |
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| Lin Zhong,CHEN Sai-zhen,YANG Xiu-fei,CHEN Hong,WANG Ai-ping. Monitoring the Concentration of Phenytoin in Serum,Saliva[J]. Strait Pharmaceutical Journal, 2005, 17(3): 144-145 |
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| Authors: | Lin Zhong CHEN Sai-zhen YANG Xiu-fei CHEN Hong WANG Ai-ping |
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| Affiliation: | LIN Zhong 1,CHEN Sai-zhen 2,YANG Xiu-fei 1,CHEN Hong 1,WANG Ai-ping 1 |
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| Abstract: | OBJECTIVE To study the relationship between conccntration of phenytion in scrum and saliva in cpileptic.METHODS To determioc the concentration of phenytion in scrum and saliva by TDxFLx.RESULTS The ratio betwccn concentration of phenytion in saliva and serum is 10.42%+1.1%.CONCLUSION Lincar correlation cxisted betwccn concentration of phenytion in serum and asliva,besides the conccnlration in saliva bc close to the free concentration in serum.this method appeared to be simplc.so this method has morc meaning in the clinic. |
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| Keywords: | Phenytion Serum Saliva Concentretion Interrelation |
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