Prognostic impact of treatment modalities on patients with single nodular recurrence of hepatocellular carcinoma |
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Authors: | Masaki Ueno Kazuhisa Uchiyama Satoru Ozawa Takayuki Nakase Naoki Togo Shinya Hayami Hiroki Yamaue |
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Institution: | (1) Second Department of Surgery, Wakayama Medical University, School of Medicine, 811-1 Kimiidera, Wakayama 641-8510, Japan |
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Abstract: | Purpose To evaluate the prognostic impact of various therapeutic modalities, such as repeat hepatectomy, ablation therapy, and transcatheter
arterial chemoembolization (TACE) therapy, used to treat single nodular recurrent hepatocellular carcinoma (HCC).
Methods Thirty-two patients with single nodular intrahepatic recurrence after curative primary resection of HCC were enrolled in this
study. The prognostic factors after recurrence were established using 13 clinicopathologic variables, including the therapeutic
modalities; namely, repeat hepatectomy, ablation therapy, or TACE therapy.
Results Of the 32 patients, 9 underwent repeat hepatectomy, 10 underwent ablation therapy, and 13 underwent TACE therapy. The therapeutic
modality was the only prognostic factor. In comparison with TACE therapy, the relative risks associated with ablation therapy
and repeat hepatectomy were 0.19 and 0.29, respectively. The 5-year survival rates after single nodular recurrence were 57%
in the ablation therapy group, 29% in the repeat hepatectomy group, and 0% in the TACE therapy group.
Conclusions Repeat hepatectomy and ablation therapy are more effective than TACE therapy for improving the prognosis of patients with
single nodular intrahepatic recurrent HCC. |
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Keywords: | Recurrent hepatocellular carcinoma Repeat hepatectomy Ablation therapy Transcatheter arterial chemoembolization |
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