| 强力宁对家兔心肌缺血再灌注损伤的保护作用 |
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| 引用本文： | 张坚松,李凤美,李友清,蔡宏伟. 强力宁对家兔心肌缺血再灌注损伤的保护作用[J]. 中南大学学报(医学版), 1997, 0(1) |
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| 作者姓名： | 张坚松 李凤美 李友清 蔡宏伟 |
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| 作者单位： | 湖南医学高等专科学校生理教研室，湖南医科大学附属湘雅医院麻醉科 |
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| 摘 要： | 以心肌组织ＭＤＡ含量和ＣＰＫ活性及超微结构变化为依据，观察强力宁对家兔心肌缺血再灌注损伤的影响。结果表明，强力宁能明显降低缺血再灌注后心肌组织ＭＤＡ含量和ＣＰＫ活性的升幅（Ｐ＜０．０１），同时，能明显减轻心肌组织超微结构损伤程度。提示强力宁对缺血再灌注损伤心肌具有明显的保护作用。
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| 关 键 词： | 再灌损伤；甘草次酸；心肌；磷酸肌酸激酶；超微结构；兔 |
EFFECTS OF GLYCYRRHISIN ON MYOCARDIAL ISCHEMIA/REPERFUSION INJURY OF RABBITS |
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| Zhang Jiansong Li Fengmei. EFFECTS OF GLYCYRRHISIN ON MYOCARDIAL ISCHEMIA/REPERFUSION INJURY OF RABBITS[J]. Journal of Central South University. Medical sciences, 1997, 0(1) |
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| Authors: | Zhang Jiansong Li Fengmei |
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| Abstract: | The content of MDA and the activity of creatine phosphokinase (CPK) together with the ultrastructural changes in myocardial tissue were analysed to observe the effects of glycyrrhisin on myocardial ischemia/reperfusion injury in rabbits. The results showed that glycyrrhisin could remarkably reduced the level of MDA and the activity of CPK in myocardial tissue ( P <0.01), and mitigated significantly the myocrdial ultrastructural injury in comparison with ischemia/reperfusion group. It was considered that glycyrrhisin exerted obvious protective effects on myocardial injury induced by ischemia/reperfusion. |
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| Keywords: | reperfusion injury glycyrrhisin * myocardium creatine phosphokinase malon dialdehyde ultrastructure rabbits |
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