| 新疣克星酊剂的制备及质量控制 |
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| 引用本文： | 曹健,张恩娟,黄林清,葛勤,田华.新疣克星酊剂的制备及质量控制[J].中国药房,2004,15(11):672-673. |
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| 作者姓名： | 曹健 张恩娟 黄林清 葛勤 田华 |
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| 作者单位： | 第三军医大学新桥医院药学部,重庆市,400037 |
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| 摘 要： | 目的制备新疣克星酊剂,并研究其质量控制方法。方法采用紫外分光光度法测定方中伐昔洛韦和鬼臼毒素的含量。结果伐昔洛韦和鬼臼毒素分别在1488～3472、1750～5012μg/ml浓度范围内与吸收度呈线性关系(r=09998、r=09999);回收率分别为1005%(RSD=031%)、1007%(RSD=092%)。结论新疣克星酊剂的制备工艺简单,质量控制方法可行。
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| 关 键 词： | 鬼臼毒素 伐昔洛韦 酊剂 制备 质量控制 |
| 文章编号： | 1001-0408(2004)11-0672-02 |
| 修稿时间： | 2003年9月9日 |
Preparation and Quality Control of Xinyoukexing Tincture |
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| CAO Jian,ZHANG Enjuan,HUANG Linqing,GE Qin,TIAN Hua.Preparation and Quality Control of Xinyoukexing Tincture[J].China Pharmacy,2004,15(11):672-673. |
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| Authors: | CAO Jian ZHANG Enjuan HUANG Linqing GE Qin TIAN Hua |
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| Abstract: | OBJECTIVE:To investigate the preparation technic and method of quality control of Xinyoukexing tincture(XYKX) METHODS:To determine the content of Valaciclovir by spectrophotography,and podophyllotoxin by dual-wavelength spectrophotography RESULTS:In the range of 14 88～34 72μg/ml,the Valaciclovir concentration in XYKX was in direct proportion to the absorption at 310 4nm,C=44 5 905A+1 7 556,r=0 9 998 In the range of 17 50～50 12μg/ml,the podophyllotoxin concentration in XYKX was in direct proportion to the absorption at 292nm,C=97 7 981Ap292+1 3 614,r=0 9 999,AP292=As292-As325 CONCLUSION:The preparation technic of XYKX is simple and the method of quality control is feasible |
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| Keywords: | podophyllotoxin Valaciclovir tincture preparation quality control |
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