复方阿嗪米特联合多潘立酮治疗功能性消化不良

目的评价复方阿嗪米特、多潘立酮及二者联合使用等不同方案对功能性消化不良（FD）的临床疗效并进行比较,探讨治疗FD的较好治疗方案。方法将110例功能性消化不良患者随机分成：单口服多潘立酮组（A组37例）、单口服复方阿嗪米特组（B组36例）及口服复方阿嗪米特和多潘立酮组（C组37例）等三组,疗程4周。采用腹胀症状评分法和进行饮水负荷试验评价各组治疗前后的改善程度。结果治疗1、2、4周后,A、B、C三组腹胀积分及均低于治疗前（P〈0.05）,B组与A组比较、C组与A组比较,P〈0.01;C组与B组比较,P〈0.05;差异有统计学意义。A、B、C三组最大饮水量变化：均大于治疗前,差异有统计学意义（P〈0.05）;B组与A组比较、C组与A组比较,P〈0.01;C组与B组比较,P〈0.05。差异有统计学意义。A、B、C三组患者治疗总有效率：1周后分别为37.8%、58.3%和81.1%,2周后分别为48.6%、75.0%和86.5%,4周后分别为54.1%、86.1%和94.6%;B组与A组比较、C组与A组比较,P〈0.01;C组与B组比较,P〈0.05;差异有统计学意义。治疗过程中各组均未出现严重药物副作用。结论复方阿嗪米特肠溶片治疗FD的临床疗效明显优于促动力药多潘立酮;而复方阿嗪米特与多潘立酮联合使用,则可获得更好的治疗功能性消化不良的临床疗效。复方阿嗪米特联合多潘立酮的治疗方案,有临床推广价值。

CLINICAL EFFECTS OF COMPOUND AZINTAMIDE COMBINED WITH DOMPERIDONE IN THE TREATMENT OF PATIENTS WITH FUNCTIONAL DYSPEPSIA

Objective To explore the effective and safe therapy methods for functional dyspepsia and compare the clinical effects of these usages such as Domperidone or Compound Azintamide alone,and Compound Azintamide combined with Domperidone.Methods 110 patients with functional dyspepsia were diagnosed and randomly divided into three groups,group A was treated with Domperidone tablets alone,group B was treated with Compound Azintamide tablets alone,group C was treated with Compound Azintamide plus Domperidone tablet...