| 前列腺癌患者手术前后外周血调节性T细胞和FOXP3mRNA的表达及临床意义 |
| |
| 引用本文： | 章更生.前列腺癌患者手术前后外周血调节性T细胞和FOXP3mRNA的表达及临床意义[J].中国慢性病预防与控制,2011,19(2):187-189. |
| |
| 作者姓名： | 章更生 |
| |
| 作者单位： | 上虞市人民医院泌尿外科,浙江,312300 |
| |
| 摘 要： | 目的探讨前列腺癌（PCa）患者手术前后外周血CD4^＋ CD25＋调节性T细胞（Tregs）及其特异标志物FOXP3mRNA的表达比例的变化及临床意义。方法应用流式细胞术检测50例前列腺癌及50例正常对照组外周血单个核细胞（PBMC）中Trigs占CD4CF细胞的比例，应用RT～PCR技术检测人外周血PBMCFOXP3mRNA的表达。结果随着Gleason分级升高，CD4^＋CD25^＋Tregs／CD4^＋T比值和FOXP3 mRNA表达量均有升高趋势；PCa患者术前CD4^＋CD25^＋Treg细胞占CD4^＋细胞的比例和FOXP3mRNA表达水平高于正常对照组（均P〈0．05），术后水平与正常对照组差异无统计学意义；PCa组Tregs表达率与FOXP3mRNA呈正相关（r=0．623，P〈0．01）。结论Tregs及其特异标志物FOXP3具有维持自身免疫稳定和抑制肿瘤免疫作用，可能参与前列腺癌的发生。
|
| 关 键 词： | 前列腺癌 CD4^＋CD25^＋调节性T细胞 FOXP3 mRNA |
Levels of CD4+CD25+Regulatory T Cells & Expression of FOXP3 mRNA after Operation in Peripheral Blood from Patients with Prostate Cancer and its Clinical Significance |
| |
| ZHANG Geng-shen.Levels of CD4+CD25+Regulatory T Cells & Expression of FOXP3 mRNA after Operation in Peripheral Blood from Patients with Prostate Cancer and its Clinical Significance[J].Chinese Journal of Prevention and Control of Chronic Non-Communicable Diseases,2011,19(2):187-189. |
| |
| Authors: | ZHANG Geng-shen |
| |
| Institution: | ZHANG Geng-shen.Shangyu People's Hospital,Zhejiang 312300,China |
| |
| Abstract: | Objective To explore the rate change of CD4+ CD25+ regulatory T cells and expression of FOXP3 mRNA after operation in peripheral blood from patients with prostate cancer and its clinical significance.Methods Flow cytometry was used to analyze the proportion of CD4+CD25+ regulatory T cells/CD4+T cells in peripheral blood mononuclear cells(PBMC) among 50 patients with prostate cancer and 50 healthy controls.The expression of FOXP3 mRNA in PBMC was detected by RT-PCR.Results The value of CD4+CD25+Tregs/CD4+ T ... |
| |
| Keywords: | Prostate cancer CD4 CD25 regulatory T cell FOXP3 mRNA |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
