| 慢性肾功能衰竭患者血清瘦素、白细胞介素-13和白细胞介素-18水平变化及其临床意义 |
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| 引用本文： | 陈美华.慢性肾功能衰竭患者血清瘦素、白细胞介素-13和白细胞介素-18水平变化及其临床意义[J].中国慢性病预防与控制,2011,19(2):178-179. |
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| 作者姓名： | 陈美华 |
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| 作者单位： | 玉环县中医院检验科,浙江,317600 |
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| 摘 要： | 目的探讨血清瘦素（leptin）、白细胞介素-13（IL—13）及白细胞介素-18（IL～18）水平在慢性肾功能衰竭患者中的变化及其临床意义。方法分别采用ELISA法和RIA检测86例慢性肾功能衰竭患者血清IL-13、IL-18和leptin含量，并与80例正常对照组比较分析。结果慢性肾功能衰竭组与正常对照组相比较，血清leptin、IL-13及IL-18水平均明显升高（P〈0．01）；慢性肾功能衰竭早期、肾衰竭期和尿毒症期患者leptin无差异（P〉0．05），而IL-13、IL～18水平随病情的加重而逐步升高（P〈0．05）；血清leptin水平与血清IL-13、IL—18水平呈正相关（r=0．527，r=-0．489；均P〈0．05），IL-13与IL-18也呈显著正相关（r=0．731，P〈0．01）。结论慢性肾功能衰竭患者leptin、IL-13及IL-18水平升高，其在慢性肾功能衰竭发生发展过程中可能起重要作用，且存在一定的相关性，IL—13和IL—18影响慢性肾功能衰竭患者的疾病进程。
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| 关 键 词： | 慢性肾功能衰竭 瘦素 白细胞介索-13 白细胞介素-18 |
Changes and Clinical Significance of Serum Leptin,IL-13 and IL-18 in Patients with Chronic Renal Failure |
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| CHEN Mei-hua.Changes and Clinical Significance of Serum Leptin,IL-13 and IL-18 in Patients with Chronic Renal Failure[J].Chinese Journal of Prevention and Control of Chronic Non-Communicable Diseases,2011,19(2):178-179. |
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| Authors: | CHEN Mei-hua |
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| Institution: | CHEN Mei-hua.Yuhuan Hospital of Traditional Chinese Medicine,Zhejiang 317600,China |
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| Abstract: | Objective To explore the changes and its clinical significance of serum.leptin,IL-13 and IL-18 in patients with chronic renal failure(CRF).Methods Serum IL-13,IL-18(with ELISA) and leptin(with RIA) levels were measured in 86 patients with CRF and 80 health control.Results The levels of serum leptin,IL-13and IL-18 levels were higher in CRF group than in the healthy control group(P<0.01);During the early stage,renal failure stage and urinaemia stage of CRF,there were no differences for all the patients in the... |
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| Keywords: | Chronic renal failure Leptin Interleukin 13 Interleukin 18 |
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