参芪扶正注射液联合化疗治疗恶性肿瘤的临床研究

目的比较参芪扶正注射液联合化疗与单纯化疗治疗恶性肿瘤的临床疗效及不良反应。方法入选的62例患者随机分为两组,观察组32例,采用参芪扶正联合化疗,平均化疗5.7周期。对照组30例,单纯化疗,平均化疗5.6周期。结果观察组完全缓解（CR）3例,部分缓解（PR）12例,稳定（NC）11例,进展（PD）6例,总有效率46.9%。对照组CR 1例,PR 9例,NC 11例,PD 9例,总有效率33.3%。治疗组与对照组比较,治疗组T细胞亚群CD3、CD4和CD4/CD8比值明显升高,差异有显著性（P〈0.01）。治疗组生活质量较对照组明显改善。结论参芪扶正注射液联合化疗治疗恶性肿瘤可以减轻化疗的不良反应,使患者化疗依从性更好,增强机体的免疫功能,改善患者生活质量。

Clinical Study of the Combined Treatment with Shenqi Fuzheng Injection and Chemotherapy for Patients with Malignant Tumor

Objective To compare the curative effect and side-effect of the combined treatment with Shenqi Fuzheng Injection and chemotherapy with only chemotherapy for patients with malignant tumors.Methods 62 cases were randomly divided into 2 groups: observation group(n=32) and control group(n=30);combined treatment was given to observation group and the treatment cycle was 5.7 on average while only chemotherapy was given control group and the cycle was 5.6 on average.Results In observation group,complete remission was found in 3 cases,partial remission in 12 cases,no changes in 11 cases and progressive deterioration in 6 cases,the total effective rate was 46.9%;in control group,complete remission was found in 1 case,partial remission in 9 cases,no changes in 11 cases and progressive deterioration in 9 cases,the total effective rate was 33.3%.After treatment,a comparison between the 2 groups showed that the level of CD3,CD4 and CD4/CD8 in observation group was much higher than that in control group,the difference was of significance(P<0.01);Quality of Life of the patients in observation group was improved much more than that of the patients in control group.Conclusions The combined treatment with Shenqi Fuzheng Injection and chemotherapy can decrease the side-effect of chemotherapy,lead to better compliance of patients,enhance immune function and improve Quality of Life.