儿童反复呼吸道感染与维生素D水平及受体基因单核苷酸多态性相关性研究

目的探讨儿童反复呼吸道感染与维生素D水平及受体基因单核苷酸多态性相关性情况。方法分析本院收治的反复呼吸道感染患儿50例和对照组研究对象的维生素D受体水平和基因频率分布。结果反复出现呼吸道感染患儿的观察组的25-羟维生素D（25-OH-Vit D）水平明显低于对照组,P〈0.05,差异有统计学意义。两组研究对象在FokI两个酶切位点的基因型分布上差异无统计学意义,P〉0.05,但是反复呼吸道感染患儿的观察组BsmI基因型Bb、bb频率和Apal基因型aa频率明显高于对照组,P〈0.05,差异有统计学意义。结论维生素D受体基因多态性和反复呼吸道感染患儿有一定的相关性。

The study on the correlation of children with recurrent respiratory infection and the level of vitamin D and single nucleotide polymorphism

Objective To approach children with recurrent respiratory infection and the level of vita min D and single nucleotide polymorphism on the correlation. Methods Analyzed Vitamin D receptor gene polymorphism and gene frequency distribution of and the control group of 50 cases of children with recurrent re spiratory tract infection in our hospital. Results The 25OHVit D level of detection group were lower than control group, P 〈 0. 05,the difference were statistical significance. No significant differences in genotype distri bution of cutting sites in the FokI two enzyme of two groups,P 〉 0. 05, but Bb,bb genotypic frequency of BsmI and aa genotypie frequency of Apal of detection group were higher than control group, P 〈 0.05, the difference were statistical significance. Conclusion The Vitamin D receptor gene polymorphism and children with recur rent respiratory tract infection has a certain correlation.