沙培林和沙培林联合顺铂胸腔内注射治疗恶性胸腔积液的疗效和安全性比较

目的比较沙培林和沙培林与顺铂联合治疗恶性胸腔积液的疗效和安全性。方法 64例恶性胸腔积液患者随机分为两组,经胸腔闭式引流管排净胸腔积液后注入药物,治疗组：生理盐水20 ml＋沙培林5KE＋2%利多卡因5 ml混合后胸腔内注射;对照组：将地塞米松10 mg、生理盐水20 ml＋沙培林5KE、生理盐水20 ml＋顺铂20 mg＋2%利多卡因5 ml次序注入胸腔。结果两组在治疗方面疗效相当,在安全性和不良反应方面治疗组要少于对照组。结论单用沙培林治疗恶性胸腔积液疗效可靠,不良反应少,痛苦少,生活质量高。

Comparison of the efficacy and safety of sapylin and sapylin plus cisplatine injected into thoracic cavity for treating malignant pleural effusion

Objective To evaluate the efficacy and safety of sapylin and sapylin plus cisplatine injec ted into thoracic cavity for treating malignant pleural effusion. Methods After malignant pleural effusion was abstracted completely out by thoracic cavity closed drainage, 64 patients with malignant pleural effusion were di vided into two groups randomly： treatment group and control group. The treatment group was given saline （20 ml） and sapylin （5KE） and 2% lidocaine into thoracic cavity; the control group was given dexamethasone （ 10 mg） firstly, then saline （20 ml） and sapylin （SKM） , at last saline （20 ml） and cisplatine （20 mg） and 2% lidocaine into thoracic cavity. Results The two groups had the similar treatment efficacy, but the safety and side effect in the treatment group was better than the control group. Conclusion Sapylin is used to cure malig nant leural effusion. The method is reliable, less side effect and less pain, and improves the quality of life.