血清PCT、CRP检测对重症急性胰腺炎合并细菌感染的诊断价值

目的探讨血清降钙素原(PCT)、C反应蛋白(CRP)检测对重症急性胰腺炎(SAP)合并细菌感染的诊断价值。方法选取2015年1月2017年8月本院收治的86例SAP合并细菌感染作为合并组,同期选取86例SAP无合并细菌感染患者作为SAP组,检测两组血清PCT、CRP水平,分析血清PCT、CRP水平对SAP合并细菌感染的诊断价值。结果合并组和SAP组第1d血清PCT、CRP水平基本相同,差异无统计学意义(P>0.05),合并组第3、7d血清PCT、CRP水平明显高于SAP组,差异有统计学意义(P<0.05);ROC曲线分析结果显示,在诊断SAP合并细菌感染的敏感度、特异度、准确度、曲线下面积(AUC)方面,血清PCT以11.50mg/L为临界值时分别为83.72%、81.40%、82.56%、0.754,血清CRP以50.00mg/L为临界值时分别为81.40%、79.07%、80.23%、0.722,血清PCT联合CRP时分别为97.67%、95.35%、96.51%、0.857,二者联合时明显高于二者单独时,差异有统计学意义(P<0.05),二者单独时比较,差异无统计学意义(P>0.05)。结论血清PCT、CRP水平与SAP合并细菌感染的发生有关,监测二者水平可作为评估SAP合并细菌感染的重要参考指标,且二者联合时具有更高的诊断价值,值得临床作进一步推广。

Diagnostic value of serum PCT and CRP detection for severe acute pancreatitis combined with bacterial infection

Objective To discuss the diagnostic value of serum procalcitonin(PCT)and C reactive protein(CRP)detection for severe acute pancreatitis(SAP)combined with bacterial infection.Methods 86 SAP patients with bacterial infection were selected as combined group from August 2017 January 2015 in our Hospital,86 SAP patients without bacterial infection were selected as SAP group at the same time,the serum PCT and CRP levels in two groups were detected.The diagnostic value of serum PCT and CRP levels for SAP combined with bacterial infection was analyzed.Results The 1 d serum PCT,CRP levels of combined group and SAP group were basically the same,the difference was not statistically significant(P>0.05),the 3,7 d serum PCT,CRP levels of combined group significantly higher than those of SAP group,the difference was statistically significant(P<0.05).The ROC curve analysis showed that,the sensitivity specificity and accuracy under the curve(AUC)in the diagnosis of SAP with bacterial infection,the serum PCT with 11.50 mg/L as the critical value were 83.72%,81.40%,82.56%,0.754,the serum CRP with 50.00 mg/L as the critical value were 81.40%,79.07%,80.23%,0.722,the serum PCT combined with CRP were 97.67%,95.35%96.51%,0.857,the two combined were significantly higher than those of the two alone,the difference was statistically significant(P<0.05),the comparison of the two alone,there was no statistically significant difference(P>0.05).Conclusions The levels of serum PCT and CRP is related to the occurrence of SAP combined with bacterial infection,monitoring the two levels can be used as an important reference index to evaluate SAP combined with bacterial infection,and the combination of the two has the higher diagnostic valu,it’s worth for further clinical promotion.