102例胸外科手术患者肺炎克雷伯菌血流感染的临床特征及其对抗菌药物的敏感性分析

目的:分析医院胸外科手术患者肺炎克雷伯菌血流感染的临床特征及其药敏试验结果,为胸外科术后肺炎克雷伯菌血流感染患者抗菌药物的合理使用提供参考.方法:抽取2015年1月-2018年1月间胸外科收治的手术治疗后并发肺炎克雷伯菌血流感染患者102例资料,分析其肺炎克雷伯菌血流感染的临床特征及其对抗菌药物药敏试验结果.结果:10...

Analysis on Clinical Characteristics of Klebsiella Pneumoniae Bloodstream Infection and Its Sensitivity to Antimicrobials in 102 Patients Undergoing Thoracic Surgery

Objective:To analyze the clinical characteristics of Klebsiella pneumoniae(KP)bloodstream infection and its sensitivity to antimicrobial agents in 102 patients undergoing thoracic surgery,and to provide reference for the rational usage of antimicrobial agents in patients with KP bloodstream infection after thoracic surgery.Methods:The data of 102 patients complicated with KP blood flow infection after surgical treatment admitted to the department of thoracic Surgery from January 2015 to January 2018 were extracted to analyze the clinical characteristics of KP blood flow infection and the results of antimicrobial susceptibility test.Results:102 strains of KP were detected in 102 patients with bloodstream infection.In different thoracic surgeries,the blood flow rate of KP was 33.33%,21.57%and 16.67%respectively in radical gastrectomy,tracheotomy and pleural puncture.Blood flow infection occurred mainly in 61.76%of male patients,60.78%of whom were aged in greater than or equal to 60 years old,36.27%of patients with radiation/chemotherapy history,30.39%of patients with minimally invasive surgery,69.61%of patients with open-heart surgery,23.53%and 29.41%of patients with diabetes and hypertension,respectively.The drug sensitivity test results showed that the drug resistance rate of KP to ampicillin was 100.00%,while the drug resistance rate of KP to furantoin,cefazolin,amoxicillin,compound sulfamethoxazole and other antibacterial drugs were all higher,but the drug resistance to other antibacterial drugs was relatively weak.It was sensitive to amikacin,meropenem and imipenem,while sensitive to gentamicin,cefepime,piperacillin,cefoperazone,ceftriaxone,levofloxacin,cefoxitin,tigecycline and ciprofloxacin were all higher than 80.00%.Conclusion:The incidence of KP infection after radical gastrectomy,tracheotomy,and pleural puncture is relatively high,especially in men who are older than 60 years old,have a history of radiotherapy or chemotherapy,accompanied by diabetes or hypertension,and the incidence of KP blood flow infection is relatively high,the cure rate is low,and the fatality rate is higher than 10.00%.In order to ensure the effectiveness of the treatment of KP blood flow infection,antimicrobial agents with high sensitivity rate should be selected reasonably based on the drug sensitivity results.