创伤后脑水肿组织腺苷酸含量变化

目的：探讨创伤后脑组织腺苷酸含量及其与脑水肿的关系。方法：将兔脑创伤性脑水肿模型按不同 时段断头处死，取损伤灶边缘脑组织测定脑水含量及用高效液相色谱仪测定组织腺苷酸含量。结果：脑创伤后组织腺革酸含量较正常对照组低，且随伤后时间延长降低更明显，与脑水肿程度一致。结论：脑创伤后组织腺苷酸随脑水肿加重而降低，具有很好的相关性。

Adenylate Content of Brain Edema Tissue After Trauma

Objection To explore adenylate content of traumatic brain edema tissue and the relationship between ad-enylate content and brain edema.Methods The 20 rabbits with traumatic brain edema were sacrificed by decapitation in different periods,other 4 rabbits brain as control group.The brain tissue in the ringed traumatic site was used to measure brain water content and adenylate including AMP,ADP and ATP contents with HPLC.Results The adenylate content of traumatic brain edema tissue was lower than that of normal brain tissue,and further obviously reduction with longitude after trauma,and consistent with brain edema extent.Condusion The adenylate content of traumatic brain tissue is reduced along with brain edema severity and there is obviously correlation.