| CK7单克隆抗体在鉴别卵巢原发性与胃肠道源性转移癌中的意义 |
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| 作者姓名： | Yang W Zhang T Shen M |
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| 作者单位： | 上海医科大学附属肿瘤医院病理科 |
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| 摘 要： | 目的研究ＣＫ７单克隆抗体在鉴别卵巢原发性癌和来源于胃肠道的卵巢转移性癌中的意义。方法采用免疫组织化学ＡＢＣ方法对４６例卵巢原发性癌、３４例原发灶在胃的卵巢转移性癌和３０例原发灶在肠的卵巢转移性癌进行了ＣＫ７单克隆抗体表达的检测。结果４６例卵巢原发性癌ＣＫ７均呈阳性表达,而３０例来源于肠的卵巢转移性癌ＣＫ７均为阴性,３４例来源于胃的卵巢转移性癌５０％呈ＣＫ７阳性表达。两组卵巢转移性癌的ＣＫ７阳性率与原发癌相比均有显著性差异（Ｐ＜０００１）。结论ＣＫ７单克隆抗体作为一个原发性卵巢癌的特异性标记,对鉴别卵巢原发性癌和来源于胃肠道的卵巢转移癌有重要意义
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| 关 键 词： | 卵巢肿瘤 肿瘤转移 诊断.鉴别 |
The role of cytokeratin 7 in the differential diagnosis of primary ovarian carcinoma and metastatic ovarian carcinoma originated from the gastrointestinal tract |
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| Yang W,Zhang T,Shen M.The role of cytokeratin 7 in the differential diagnosis of primary ovarian carcinoma and metastatic ovarian carcinoma originated from the gastrointestinal tract[J].Chinese Journal of Pathology,1998,27(3):206-208. |
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| Authors: | Yang W Zhang T Shen M |
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| Institution: | Department of Pathology, Shanghai Medical University, Cancer Hospital, 200032. |
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| Abstract: | Objective To assess the role of cytokeratin 7 monoclonal antibody in the differential diagnosis of primary ovarian carcinoma and metastatic ovarian carcinoma originated from the gastrointestinal tract. Methods Immunohistochemical study using cytokeratin 7 monoclonal antibody and ABC kit. Results All the 46 cases of primary ovarian carcinoma were CK 7 positive, while in the metastatic ovarian carcinoma of intestinal origin, all cases remained negative for CK7. Half of the 34 cases of metastatic ovarian carcinoma of gastric origin were CK 7 positive. The positive result of CK7 was significantly higher in the primary ovarian carcinoma than in each group of the metastatic ovarian carcinoma ( P <0.001). Conclusion CK 7 is seemed to be a useful antibody in the differential diagnosis of ovarian carcinoma. |
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| Keywords: | Ovarian neoplasms Neoplasm metastasis Diagnosis Differential |
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