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Malignant catatonia due to anti-NMDA-receptor encephalitis in a 17-year-old girl: case report |
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| Authors: | Angèle Consoli Karine Ronen Isabelle An-Gourfinkel Martine Barbeau Donata Marra Nathalie Costedoat-Chalumeau Delphine Montefiore Philippe Maksud Olivier Bonnot Adrien Didelot Zahir Amoura Marie Vidailhet David Cohen |
| Affiliation: | 1. Department of Child and Adolescent Psychiatry, Université Pierre et Marie Curie, H?pital Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l’H?pital, 75013, Paris, France 2. Department of Neurology, Université Pierre et Marie Curie, H?pital Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l’H?pital, 75013, Paris, France 3. Department of Internal Medicine, Université Pierre et Marie Curie, H?pital Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l’H?pital, 75013, Paris, France 5. Department of Adult Psychiatry, Université Pierre et Marie Curie, H?pital Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l’H?pital, 75013, Paris, France 4. Department of Nuclear Medicine, Université Pierre et Marie Curie, H?pital Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l’H?pital, 75013, Paris, France 6. Reference center of paraneoplastic neurological syndrome diagnosis and treatment, H?pital Pierre Wertheimer, 59, bld Pinel, 69 003, Lyon, France |
| Abstract: | Anti-NMDA-Receptor encephalitis is a severe form of encephalitis that was recently identified in the context of acute neuropsychiatric presentation. Here, we describe the case of a 17-year-old girl referred for an acute mania with psychotic features and a clinical picture deteriorated to a catatonic state. Positive diagnosis of anti-NMDA-receptor encephalitis suggested specific treatment. She improved after plasma exchange and immunosuppressive therapy. Post-cognitive sequelae (memory impairment) disappeared within 2-year follow-up and intensive cognitive rehabilitation. |
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