Chronic lithium treatment diminishes the female advantage in lifespan in Drosophila melanogaster |
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| Authors: | Fengge Zhu Qinggang Li Fujian Zhang Xuefeng Sun Guangyan Cai Weiguang Zhang Xiangmei Chen |
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| Affiliation: | Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing, China |
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| Abstract: | Two studies have concluded that lithium exposure extends the lifespan of Caenorhabditis elegans. However, the effect of lithium on another widely used model organism, Drosophila melanogaster, remains unclear. Here, we demonstrate that chronic treatment with a low to moderate dose of lithium chloride does not extend lifespan in D. melanogaster and that the drug abolishes the female lifespan advantage in flies. |
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| Keywords: | ageing lithium sex difference |
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