首页 | 本学科首页   官方微博 | 高级检索  
检索        


Anti‐inflammatory properties of resveratrol in the retinas of type 2 diabetic rats
Authors:Farhad Ghadiri Soufi  Elham Arbabi‐Aval  Mozhgan Rezaei Kanavi  Hamid Ahmadieh
Institution:1. Molecular Medicine Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran;2. Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract:Resveratrol (trans‐3,5,4′‐trihydroxystilbene) is a nutritional supplement with anti‐inflammatory properties. The present study investigated the long‐term anti‐inflammatory property of resveratrol in the retinas of type 2 diabetic rats. Male Wistar rats were divided into four groups: normal control, diabetic control, resveratrol‐treated normal rats and resveratrol‐treated diabetic rats. Type 2 diabetes was induced by a single dose injection of streptozotocin (50 mg/kg; i.p.) 15 min after the administration of nicotinamide (110 mg/kg; i.p.) in 12‐h fasted rats (the streptozotocin–nicotinamide type 2 diabetic model). Oral resveratrol administration (5 mg/kg per day for 4 months) significantly improved glucose tolerance, and alleviated hyperglycemia and weight loss in diabetic rats. Furthermore, resveratrol administration significantly decreased the elevated levels of nuclear factor‐κB activity, and mRNA expression, tumour necrosis factor alpha level and apoptotic cells in the retinas of the diabetic rats. Furthermore, resveratrol did not significantly affect plasma insulin levels. Long‐term resveratrol administration has beneficial anti‐inflammatory properties in a rat model of diabetes. However, whether resveratrol exerts its effects directly or through reducing blood glucose levels requires further investigation.
Keywords:diabetic retinopathy  nuclear factor‐κ  B  polyphenol  resveratrol  streptozotocin–  nicotinamide model
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号