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| 平阳霉素引发细胞凋亡与MAPK信号转导通路的关联性 | |
| 引用本文： | 戴国维,张震康,于世凤,周明勇. 平阳霉素引发细胞凋亡与MAPK信号转导通路的关联性[J]. 中华口腔医学杂志, 2002, 37(2): 97-98 |
| 作者姓名： | 戴国维 张震康 于世凤 周明勇 |
| 作者单位： | 1. 北京大学口腔医学院口腔颌面外科,100081 2. 北京大学口腔医学院病理科,100081 3. 台湾中山医学院牙医学系 |
| 摘 要： | 目的 探讨平阳霉素引发细胞凋亡与分裂原激活的蛋白激酶家族（mitogen-activated protein kinase,MAPK)信号转导通路的关联性。方法 采用Western印迹法（western blot)检测分裂原激活蛋白激酶的表达。结果 平阳霉素作用KB细胞，随作用时间延长或药物浓度增加，磷酸化细胞外信号调节激酶的表达越不明显；而p-38MAPK蛋白激酶的表达无明显变化。结论 平阳霉素引发细胞凋亡与分裂原激活的蛋白激酶家族信号转导通路有关。 |
| 关 键 词： | 蛋白激酶类 平阳霉素 细胞凋亡 MAPK 信号转导通路 抗癌药 关联性 |
| 修稿时间： | 2001-04-23 |
The role of mitogen-activated protein kinase(MAPK) pathway in the action mechan ism of PYM-induced KB cells apoptosis |
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| DAI Guowei ,ZHANG Zhenkang,ZHOU Mingyong,YU Shifeng. The role of mitogen-activated protein kinase(MAPK) pathway in the action mechan ism of PYM-induced KB cells apoptosis[J]. Chinese journal of stomatology, 2002, 37(2): 97-98 | |
| Authors: | DAI Guowei ZHANG Zhenkang ZHOU Mingyong YU Shifeng |
| Affiliation: | Department of Oral and Maxillofacial Surgery, Peking University School of Stomatolog, Beijing 100081, China. |
| Abstract: | Objective To study the role of mitogen activated protein kinase(MAPK)pathway in the action mechanism of PYM induced KB cell apoptosis.Methods Western blot analysis was used to investigate the expression of the mitogen activated protein kinase.Results When treated with PYM in cultured KB cells, the extracellular signal regulated kinase(ERKl/2)showed a dose and time dependent decreasing in phosphorylation status of these proteins through a western blot analysis,whereas protein levels of p38 MAPK remained unchanged. Conclusions The mitogen activated protein kinase(MAPK) pathway may play an important ro1e in PYM induced apoptosis of KB cells. |
| Keywords: | Protein kinases Pingyangmycin |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |