Tissue remodeling of rat pulmonary artery in hypoxic breathing. II. Course of change of mechanical properties

When cells and the matrix of a tissue remodel, the mechanical properties of the tissue do change. The mechanical properties are expressed by constitutive equations. In this article the remodeling of the constitutive equation of the pulmonary artery is studied. The remodeling was induced in a rat breathing a gas whose oxygen concentration was suddenly decreased as a step function of time and maintained constant (17.2%, 13.6%, or 10%) afterwards. Since the mathematical form of the constitutive equation has been identified in earlier papers, we need to determine only the elastic constants that change in the process of tissue remodeling. We consider arteries subjected to blood pressure and longitudinal stretch, and limit ourselves to two-dimensional problems involving only circumferential and longitudinal stress and strain. In the neighborhood of an in vivo state, the perturbations of stresses and strains are related by linear, anisotropic, tensor equations involving three elastic constants: the incremental Young's modulus in the circumferential direction Y , that in the longitudinal direction Y_zz, and the cross modulus Y_z Over a 24 h period, changes of Y between 164 and 187 kN/m² Y_zz between 64 and 92 kN/m² and Y _z between 61 and 88 kN/m² are statistically insignificant. © 2001 Biomedical Engineering Society. PAC01: 8719Rr, 8719Uv