| 致敏受者细胞因子基因多态性与肾移植急性排斥反应的关系 |
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| 摘 要： |
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| 关 键 词： | 细胞因子 基因多态性 肾移植 急性排斥反应 肿瘤坏死因子-α 白介素-10 转化生长因子-β1 干扰素-γ |
Cytokine gene polymorphism in sensitized kidney transplant recipients and its association with acute rejection episodes] |
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| Authors: | Xin-wei Gu Ming Zhao Liu-yang Li Min Li Jun Qian |
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| Institution: | Department of Organ Transplantation, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China. |
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| Abstract: | OBJECTIVE: To investigate the relationship between cytokine gene polymorphism in sensitized kidney transplant recipients and acute rejection episodes. METHODS: PCR using sequence-specific primer (PCR-SSP) was performed to determine the cytokine genotypes of tumor necrosis factor-alpha (TNF-alpha), interleukin-10 (IL-10), transforming growth factor-beta1 (TGF-beta1), interleukin-6 (IL-6), interferon-gamma (IFN-gamma) in 97 sensitized kidney transplant recipients. The association of cytokine genotypes with early graft rejection was explored. RESULTS: Acute rejection occurred in 23 of the 97 patients during the first three months after operation. The incidence of acute rejection was higher in the recipients with high TNF-alpha or high IL-10 producer genotype (51.9% and 55.5% respectively) than in the recipients with low TNF-alpha or low to intermediate IL-10 producer genotype (12.9% and 13.3% respectively, P<0.01). The incidence of acute rejection was even higher in the recipients with high TNF-alpha in combination with intermediate to high IL-10 producer genotype than in the recipients with low TNF-alpha combined with low IL-10 producer genotype (62.5% vs 8.5%, P
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