Enhanced anxiety follows withdrawal from subchronic exposure to phencyclidine in rats |
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Authors: | Audet Marie-Claude Goulet Sonia Doré François Y |
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Affiliation: | Ecole de psychologie, Université Laval, Canada; Centre de Recherche Université Laval Robert-Giffard (CRULRG), 2601 de la Canardière, F-6500, Beauport, Québec, Canada G1J 2G3. |
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Abstract: | Anxiety was assessed in rats treated with 5mg/kg of PCP bid for 7 days. One week after withdrawal, measures were collected in the light/dark apparatus and during exposure to a cat odor. PCP decreased time spent in the lit area and number of contacts with a cat collar. PCP thus amplified rats' fear of unprotected environments and predatory threats, which seems compatible with the distorted emotional experience in human schizophrenia. |
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