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盐酸青藤碱多囊脂质体的制备及其释放特性研究
引用本文:姜素芳,姚瑶,陶昱斐,丁燕飞,向璧妤. 盐酸青藤碱多囊脂质体的制备及其释放特性研究[J]. 中草药, 2008, 39(8): 1158-1161
作者姓名:姜素芳  姚瑶  陶昱斐  丁燕飞  向璧妤
作者单位:1. 湖南师范大学医学院,湖南长沙,410006
2. 中南大学药学院,湖南长沙,410006
摘    要:目的制备包封率较高且具有较好缓释性能的盐酸青藤碱多囊脂质体。方法用复乳法制备盐酸青藤碱多囊脂质体,以包封率和囊形为考察指标,采用均匀设计优选最佳处方和工艺,并考察其形状、粒径及体外释放性能。结果制得的盐酸青藤碱多囊脂质体包封率在80%以上,形状圆整,粒径较均匀,多数分布在20~30μm,体外释放符合Higuchi方程,释药t1/2为52.7 h。结论盐酸青藤碱多囊脂质体处方工艺稳定可行,包封率高且具有良好的缓释特性。

关 键 词:盐酸青藤碱  多囊脂质体  缓释  释放特性
收稿时间:2007-10-28

Preparationand release character of sinomenine hydrochloride multivesicular liposomes
JIANG Su-fang,YAO Yao,TAO Yu-fei,DING Yan-fei and XIANG Bi-yu. Preparationand release character of sinomenine hydrochloride multivesicular liposomes[J]. Chinese Traditional and Herbal Drugs, 2008, 39(8): 1158-1161
Authors:JIANG Su-fang  YAO Yao  TAO Yu-fei  DING Yan-fei  XIANG Bi-yu
Affiliation:JIANG Su-fang1,YAO Yao2,TAO Yu-fei2,DING Yan-fei2,XIANG Bi-yu1
Abstract:Objective: To prepare the sinomenine hydrochloride multivesicular liposomes with high antrapment efficiency and sustained release character. Methods: Multiple emulsion method was used to prepare the sinomenine hydrochloride muhivesicular liposomes. Uniform designwas applied to optimize the formulation and pharmaceutical process. The shape, the particle size, and the release charcter of the liposome were evaluated. Results: The sinomenine hydrochloride multivesicular liposomes prepared were spherical and the size ofmajority particleswas in therangeof 20-30um and well distributed. The encapsulation efficiency was more than 80%and its in-vitro release profile accorded well with the Higuchimodel with t1/2 up to 52. 7 h. Conclusion: The formulation and pharmaceutical processof the sinomenineby-drochloride multivesicular liposomesare stable and feasible with the high encapsulation efficiency and good sustained-release character.
Keywords:sinomenine hydrochloride  multivesicular liposomes  sustained release  release character
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