Endothelin-like immunoreactivity in aqueous humor of patients with primary open-angle glaucoma and cataract |
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| Authors: | Walter Noske Johannes Hensen Michael Wiederholt |
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| Affiliation: | (1) Department of Ophthalmology, Benjamin Franklin University Hospital, Free University of Berlin, Berlin, Germany;(2) Department of Internal Medicine, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany;(3) Department of Clinical Physiology, Benjamin Franklin University Hospital, Free University of Berlin, D-12200 Berlin, Germany |
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| Abstract: |  Background: Experimental evidence suggests a role of endothelin-1 (ET) in the regulation of intraocular pressure (IOP). Method: Therefore, inpatients undergoing cataract surgery, ET-like immunoreactivity (STIR) was measured by radioimmunoassay in pooled samples of aqueous humor of eyes with primary open-angle glaucoma (POAG) and normotensive eyes with cataract only. Results: ETIR was significantly (P < 0.05) higher in patients with cataract and POAG (20.5 ± 1.8 pg/ml,n = 12; preoperative IOP 21.4 ± I.1 mmHg,n = 33) than in patients with cataract only (15.8 ± 1.6 pg/m1,n = 15; preoperative IOP 16.0 ± 0.6 mmHg,n = 77). Conclusion: This finding may indicate a role of ET in POAG or ocular antihypertensive treatment, and its relevance should be further investigated. |
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