左西孟旦注射液治疗急性失代偿性心力衰竭42例

目的 探讨左西孟旦注射液对急性失代偿性心力衰竭患者的疗效及其对患者治疗前后血K＋、Ca2＋、射血分数（％）、每搏输出量（mL）的影响.方法 选取医院2012年收治的急性失代偿性心力衰竭患者82例,随机分为对照组（40例）和观察组（42例）.对照组患者采用常规性治疗,观察组在对照组治疗基础上应用左西孟旦注射液静脉滴注,观察两组患者临床疗效及症状缓解时间,并分析两组患者治疗后血液流变学及血小板聚集功能变化情况.结果 显效率及总有效率对照组患者分别为50.00％和72.50％,观察组患者分别为66.67％和90.48％,观察组患者临床疗效显著优于对照组（P＜0.05）.观察组患者心率减慢时间、紫绀缓解时间及浮肿消退时间显著短于对照组（P＜0.05）.观察组血K＋、射血分数、每搏输出量等指标较治疗前及对照组有明显改善（P＜0.05）,而观察组血Ca2＋与治疗前比较无明显差别（P＞0.05）,对照组用药后血Ca2＋较治疗前升高（P＜0.05）.结论 左西孟旦注射液能有效改善急性失代偿性心力衰竭患者血液流变学及血小板聚集功能,对急性失代偿性心力衰竭患者可起到较好的治疗效果,值得临床应用.

Efficacy of Levosimendan Injection in Treating Acute Decompensated Heart Failure

Objective To investigate the efficacy of Levosimendan Injection in treating acute decompensated heart failure and its impact on blood K＋,Ca2 ＋,ejection fraction （％） and stroke volume （mL） of patients before and after treatment.Methods Eighty-two patients with acute decompensated heart failure admitted to our hospital in 2012 were randomly divided into the control group（40 cases） and the observation group（42 cases）.The control group adopted the conventional treatment,while the observation group was intravenously dripped by Levosimendan Injection on the basis of the control group treatment.The clinical curative effects and symptoms alleviating time were observed in the two groups,and the changes of hemorheology and platelet aggregation function were analyzed.Results The markedly effective rate and the total effective rate were 50.00％ and 72.50％ in the control group,and 66.67％ and 90.48％ in the observation group,the clinical effects in the observation group were significantly superior to those in the control group（P＜0.05）.The time of decreased heart rate,cyanosis alleviating time and swelling subsided time in the observation group were significantly shorter than those in the control group（P＜ 0.05）.The indicators of blood K＋,ejection fraction and stroke volume in the observation group were significantly improved than before treatment and the control group（P ＜ 0.05）.But blood Ca2＋ in the observation group had no statistical significance compared with before treatment（P ＞ 0.05）.Blood Ca2＋ in the control group was increased than before treatment（P＜ 0.05）.Conclusion Levosimendan Injection can effectively improve the hemorheology and the platelet aggregation function,and has better therapeutic effect in the patients with acute decompensated heart failure,which is worthy of clinical application.