首页 | 本学科首页   官方微博 | 高级检索  
检索        


Association analysis of <Emphasis Type="Italic">SLC22A4</Emphasis>, <Emphasis Type="Italic">SLC22A5</Emphasis> and <Emphasis Type="Italic">DLG5</Emphasis> in Japanese patients with Crohn disease
Authors:Keiko?Yamazaki  Masakazu?Takazoe  Torao?Tanaka  Toshiki?Ichimori  Susumu?Saito  Aritoshi?Iida  Yoshihiro?Onouchi  Akira?Hata  Email author" target="_blank">Yusuke?NakamuraEmail author
Institution:(1) Laboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan;(2) Department of Medicine, Division of Gastroenterology, Social Insurance Central General Hospital, Tokyo, Japan;(3) Department of Medicine, Division of Gastroenterology, Suzaki Kuroshio Hospital, Kouchi, Japan;(4) Laboratory for Genotyping, SNP Research Center, The Institute of Physical and Chemical Research (RIKEN), Kanagawa, Japan;(5) Laboratory for Gastrointestinal Diseases, SNP Research Center, The Institute of Physical and Chemical Research (RIKEN), Kanagawa, Japan
Abstract:Crohn disease (CD) is an inflammatory bowel disease characterized by chronic transmural, segmental, and typically granulomatous inflammation of the gut. Recently, two novel candidate gene loci associated with CD, SLC22A4 and SLC22A5 on chromosome 5 known as IBD5 and DLG5 on chromosome 10, were identified through association analysis of Caucasian CD patients. We validated these candidate genes in Japanese patients with CD and found a weak but possible association with both SLC22A4 (P=0.028) and DLG5 (P=0.023). However, the reported genetic variants that were indicated to be causative in the Caucasian population were completely absent in or were not associated with Japanese CD patients. These findings imply significant differences in genetic background with CD susceptibility among different ethnic groups and further indicate some difficulty of population-based studies.
Keywords:Crohn disease  Single-nucleotide polymorphism (SNP)  DLG5  SLC22A4  SLC22A5  OCTN1  OCTN2  Japanese population
本文献已被 PubMed SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号